Genetic analyses have shaped much of our understanding of cancer. However, it is becoming
increasingly clear that cancer cells display features of normal tissue organization, where …

On the subject of acute myeloid leukemia (AML), there is little consensus about the target cell
within the hematopoietic stem cell hierarchy that is susceptible to leukemic transformation, …

In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of
initiating lesions, and order of subsequent mutations remain poorly understood, as AML is …

MOST human acute myeloid leukaemia (AML) cells have limited proliferative capacity,
suggesting that the leukaemic clone may be maintained by a rare population of stem cells 1–5 . …

Colon cancer is one of the best-understood neoplasms from a genetic perspective 1 , 2 , 3 ,
yet it remains the second most common cause of cancer-related death, indicating that some …

Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy
of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases …

Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis,
exemplifies the classically held view of stepwise cancer development 1 . The current model of …

A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell
model for tumor development and progression. The meeting participants were charged with …

The long-term survival of patients with acute myeloid leukemia (AML) is dismally poor. A
permanent cure of AML requires elimination of leukemic stem cells (LSCs), the only cell type …

Although uncontrolled proliferation is a distinguishing property of a tumor as a whole, the
individual cells that make up the tumor exhibit considerable variation in many properties, …