The role of the Notch signaling pathway in tumor development is complex, with Notch1
functioning either as an oncogene or as a tumor suppressor in a context-dependent manner. To …

INTRODUCTION: Tracer kinetic modeling used in conjunction with positron emission tomography
(PET) is an excellent tool for the noninvasive quantification of physiological, biological …

Purpose: To quantify the effectiveness of anti-VEGF antibodies (bevacizumab and B20-4.1.1)
as mitigators of radiation-induced, central nervous system (brain) necrosis in a mouse …

Copper(II)-diacetyl-bis(N 4 -methylthiosemicarbazone) (copper-ATSM) is a hypoxia-avid
tracer for the selective identification of hypoxic tissue. Using canine models of hypoxic …

Neurocognitive deficits are serious sequelae that follow cranial irradiation used to treat patients
with medulloblastoma and other brain neoplasms. Cranial irradiation causes apoptosis …

Optical-resolution photoacoustic microscopy (OR-PAM) is an emerging technique that directly
images optical absorption in tissue at high spatial resolution. To date, the majority of OR-…

Purpose The goal of this study was to quantify the relationship between the 1 H longitudinal
relaxation rate constant, R 1 , and oxygen (O 2 ) concentration (relaxivity, r 1 ) in tissue and …

Purpose The purpose of this study was to directly compare two isotopic metabolic imaging
approaches, hyperpolarized (HP) 13 C MRI and deuterium metabolic imaging (DMI), for …

Purpose: Immunodeficient mice serve as critical hosts for transplantation of xenogeneic cells
for in vivo analysis of various biological processes. Because investigators typically select …

We assessed the use of magnetic resonance imaging (MRI) to define placental hypoxic
injury associated with fetal growth restriction. On embryonic day 18.5 (E18.5) we utilized …