Results Forty-eight heavily pretreated patients were accrued to this study. Thromboembolic
events (12.5%), hypertension (12.5%), hypophosphatemia (6%), and thrombocytopenia (6%) …

Background Although the use of magnetic resonance imaging (MRI) for the diagnosis of
acute stroke is increasing, this method has not proved more effective than computed …

ContextNoncontrast computed tomography (CT) is the standard brain imaging study for the
initial evaluation of patients with acute stroke symptoms. Multimodal magnetic resonance …

Background Neonatal-onset multisystem inflammatory disease is characterized by fever,
urticarial rash, aseptic meningitis, deforming arthropathy, hearing loss, and mental retardation. …

Background Autoinflammatory diseases manifest inflammation without evidence of infection,
high-titer autoantibodies, or autoreactive T cells. We report a disorder caused by mutations …

Neurofibromatosis type 2 is an autosomal-dominant multiple neoplasia syndrome that results
from mutations in the NF2 tumour suppressor gene located on chromosome 22q. It has a …

Primary CNS lymphoma (PCNSL) harbors mutations that reinforce B cell receptor (BCR)
signaling. Ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, targets BCR signaling and is …

Adaptation to hypoxia is critical for survival and regulates multiple processes, including
erythropoiesis and vasculogenesis. Chuvash polycythemia is a hypoxia-sensing disorder …

Objective: To determine the frequency and nature of leptomeningeal contrast enhancement
in multiple sclerosis (MS) via in vivo 3-tesla postcontrast T2-weighted, fluid-attenuated …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized
by cortical and spinal motor neuron dysfunction. Routine magnetic resonance imaging (…