Nicotine activation of α4* receptors: sufficient for reward, tolerance, and sensitization

AR Tapper, SL McKinney, R Nashmi, J Schwarz… - Science, 2004 - science.org
The identity of nicotinic receptor subtypes sufficient to elicit both the acute and chronic effects
of nicotine dependence is unknown. We engineered mutant mice with α4 nicotinic subunits …

[HTML][HTML] A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice

…, T Arendt, MH De Angelis, J Fischer, J Schwarz… - Cell, 2009 - cell.com
It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have
been positively selected during human evolution due to effects on aspects of speech and …

Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells

…, M Maisel, H Lerche, J Schwarz… - Journal of cell …, 2004 - journals.biologists.com
Clonogenic neural stem cells (NSCs) are self-renewing cells that maintain the capacity to
differentiate into brain-specific cell types, and may also replace or repair diseased brain tissue. …

Psychosis pathways converge via D2High dopamine receptors

P Seeman, J Schwarz, JF Chen, H Szechtman… - Synapse, 2006 - Wiley Online Library
The objective of this review is to identify a target or biomarker of altered neurochemical
sensitivity that is common to the many animal models of human psychoses associated with street …

Increased muscle activity during rapid eye movement sleep correlates with decrease of striatal presynaptic dopamine transporters. IPT and IBZM SPECT imaging in …

…, JF Gildehaus, CT Wetter, C Trenkwalder, J Schwarz… - Sleep, 2003 - academic.oup.com
Study Objectives: Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized
by complex behavior during REM sleep. The etiology of this disorder is still unknown, but …

Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells

…, BO Boehm, PM Carvey, A Kupsch, J Schwarz - Experimental …, 2001 - Elsevier
We report on generation of dopamine neurons from long-term cultures of human fetal
mesencephalic precursor cells. These CNS precursor cells were successfully expanded in vitro …

Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study

A Gerhard, J Schwarz, R Myers, R Wise, RB Banati - Neuroimage, 2005 - Elsevier
We obtained [ 11 C](R)-PK11195 PET scans in six patients at different time points between
3 and 150 days after onset of ischemic stroke in order to measure the time course of …

Transcriptional Profiles of CD133+ and CD133 Glioblastoma-Derived Cancer Stem Cell Lines Suggest Different Cells of Origin

…, D Beier, K Meyer, P Kumar, A Hermann, J Schwarz… - Cancer research, 2010 - AACR
Glioblastoma multiforme (GBM) is paradigmatic for the investigation of cancer stem cells (CSC)
in solid tumors. Growing evidence suggests that different types of CSC lead to the …

[PDF][PDF] RGS9 modulates dopamine signaling in the basal ganglia

Z Rahman, J Schwarz, SJ Gold, V Zachariou, MN Wein… - Neuron, 2003 - cell.com
Regulators of G protein signaling (RGS) modulate heterotrimeric G proteins in part by serving
as GTPase-activating proteins for Gα subunits. We examined a role for RGS9-2, an RGS …

Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open …

…, M Schulz, T Schütz, J Schwarz… - The Lancet …, 2021 - thelancet.com
Background SARS-CoV-2 entry in human cells depends on angiotensin-converting enzyme
2, which can be upregulated by inhibitors of the renin–angiotensin system (RAS). We aimed …