User profiles for Johannes A. Sake
Johannes A. SakePhD Candidate, Trinity College Dublin Verified email at tcd.ie Cited by 142 |
[HTML][HTML] In vitro and ex vivo models in inhalation biopharmaceutical research—advances, challenges and future perspectives
Oral inhalation results in pulmonary drug targeting and thereby reduces systemic side effects,
making it the preferred means of drug delivery for the treatment of respiratory disorders …
making it the preferred means of drug delivery for the treatment of respiratory disorders …
[HTML][HTML] Organic cation transporters in the lung—current and emerging (patho) physiological and pharmacological concepts
Organic cation transporters (OCT) 1, 2 and 3 and novel organic cation transporters (OCTN)
1 and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of …
1 and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of …
[HTML][HTML] PET imaging to assess the impact of P-glycoprotein on pulmonary drug delivery in rats
Several drugs approved for inhalation for the treatment of pulmonary diseases are substrates
of the adenosine triphosphate-binding cassette (ABC) transporter P-glycoprotein (P-gp). P-…
of the adenosine triphosphate-binding cassette (ABC) transporter P-glycoprotein (P-gp). P-…
[HTML][HTML] Impact of P-gp and BCRP on pulmonary drug disposition assessed by PET imaging in rats
P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are two efflux transporters
which are expressed in the apical (ie airway lumen-facing) membranes of lung epithelial …
which are expressed in the apical (ie airway lumen-facing) membranes of lung epithelial …
Assessing the activity of multidrug resistance–associated protein 1 at the lung epithelial barrier
Multidrug resistance–associated protein 1 (adenosine triphosphate–binding cassette
subfamily C member 1 [ABCC1]) is abundantly expressed at the lung epithelial barrier, where it …
subfamily C member 1 [ABCC1]) is abundantly expressed at the lung epithelial barrier, where it …
[HTML][HTML] Knockout of ABCC1 in NCI-H441 cells reveals CF to be a suboptimal substrate to study MRP1 activity in organotypic in vitro models
Multidrug resistance-associated protein 1 (MRP1/ABCC1) is an efflux transporter responsible
for the extrusion of endogenous substances as well as xenobiotics and their respective …
for the extrusion of endogenous substances as well as xenobiotics and their respective …
[HTML][HTML] Tobacco smoke and inhaled drugs alter expression and activity of multidrug resistance-associated protein-1 (MRP1) in human distal lung epithelial cells in …
…, AS Delmas, L Springer, V Zoufal, JA Sake… - … in bioengineering and …, 2020 - frontiersin.org
Multidrug resistance-associated protein-1 (MRP1/ABCC1) is highly expressed in human lung
tissues. Recent studies suggest that it significantly affects the pulmonary disposition of its …
tissues. Recent studies suggest that it significantly affects the pulmonary disposition of its …
[HTML][HTML] Fyn-kinase and caveolin-1 in the alveolar epithelial junctional adherence complex contribute to the early stages of pulmonary fibrosis
Current pathophysiological findings indicate that damage to the alveolar epithelium plays a
decisive role in the development of idiopathic pulmonary fibrosis (IPF). The available …
decisive role in the development of idiopathic pulmonary fibrosis (IPF). The available …
In vitro antioxidant and wound healing properties of baru nut extract (Dipteryx alata Vog.) in pulmonary epithelial cells for therapeutic application in chronic …
Baru nuts (Dipteryx alata Vog.) are a native species from Brazil, rich in phenols and other
antioxidants, with high socioeconomic value and possible pharmaceutical applications. Here …
antioxidants, with high socioeconomic value and possible pharmaceutical applications. Here …
Possible detrimental effects of beta‐2‐microglobulin knockout in pigs
HJ Sake, A Frenzel, A Lucas‐Hahn… - …, 2019 - Wiley Online Library
Background Despite major improvements in pig‐to‐primate xenotransplantation, long‐term
survival of xenografts is still challenging. The major histocompatibility complex (MHC) class I, …
survival of xenografts is still challenging. The major histocompatibility complex (MHC) class I, …