User profiles for Johannes A. Sake

Johannes A. Sake

PhD Candidate, Trinity College Dublin
Verified email at tcd.ie
Cited by 142

[HTML][HTML] In vitro and ex vivo models in inhalation biopharmaceutical research—advances, challenges and future perspectives

MA Selo, JA Sake, KJ Kim, C Ehrhardt - Advanced Drug Delivery Reviews, 2021 - Elsevier
Oral inhalation results in pulmonary drug targeting and thereby reduces systemic side effects,
making it the preferred means of drug delivery for the treatment of respiratory disorders …

[HTML][HTML] Organic cation transporters in the lung—current and emerging (patho) physiological and pharmacological concepts

MA Selo, JA Sake, C Ehrhardt, JJ Salomon - International Journal of …, 2020 - mdpi.com
Organic cation transporters (OCT) 1, 2 and 3 and novel organic cation transporters (OCTN)
1 and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of …

[HTML][HTML] PET imaging to assess the impact of P-glycoprotein on pulmonary drug delivery in rats

…, M Sauberer, T Wanek, J Stanek, JA Sake… - Journal of Controlled …, 2022 - Elsevier
Several drugs approved for inhalation for the treatment of pulmonary diseases are substrates
of the adenosine triphosphate-binding cassette (ABC) transporter P-glycoprotein (P-gp). P-…

[HTML][HTML] Impact of P-gp and BCRP on pulmonary drug disposition assessed by PET imaging in rats

…, M Löbsch, J Stanek, T Wanek, JA Sake… - Journal of Controlled …, 2022 - Elsevier
P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are two efflux transporters
which are expressed in the apical (ie airway lumen-facing) membranes of lung epithelial …

Assessing the activity of multidrug resistance–associated protein 1 at the lung epithelial barrier

S Mairinger, JA Sake, IH Lozano, T Filip… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Multidrug resistance–associated protein 1 (adenosine triphosphate–binding cassette
subfamily C member 1 [ABCC1]) is abundantly expressed at the lung epithelial barrier, where it …

[HTML][HTML] Knockout of ABCC1 in NCI-H441 cells reveals CF to be a suboptimal substrate to study MRP1 activity in organotypic in vitro models

JA Sake, MA Selo, L Burtnyak, HE Dähnhardt… - European Journal of …, 2023 - Elsevier
Multidrug resistance-associated protein 1 (MRP1/ABCC1) is an efflux transporter responsible
for the extrusion of endogenous substances as well as xenobiotics and their respective …

[HTML][HTML] Tobacco smoke and inhaled drugs alter expression and activity of multidrug resistance-associated protein-1 (MRP1) in human distal lung epithelial cells in …

…, AS Delmas, L Springer, V Zoufal, JA Sake… - … in bioengineering and …, 2020 - frontiersin.org
Multidrug resistance-associated protein-1 (MRP1/ABCC1) is highly expressed in human lung
tissues. Recent studies suggest that it significantly affects the pulmonary disposition of its …

[HTML][HTML] Fyn-kinase and caveolin-1 in the alveolar epithelial junctional adherence complex contribute to the early stages of pulmonary fibrosis

V Menzel, M Ziegler, N Hante, JA Sake… - European Journal of …, 2022 - Elsevier
Current pathophysiological findings indicate that damage to the alveolar epithelium plays a
decisive role in the development of idiopathic pulmonary fibrosis (IPF). The available …

In vitro antioxidant and wound healing properties of baru nut extract (Dipteryx alata Vog.) in pulmonary epithelial cells for therapeutic application in chronic …

JC Coco, JA Ataide, JA Sake… - Natural Product …, 2022 - Taylor & Francis
Baru nuts (Dipteryx alata Vog.) are a native species from Brazil, rich in phenols and other
antioxidants, with high socioeconomic value and possible pharmaceutical applications. Here …

Possible detrimental effects of beta‐2‐microglobulin knockout in pigs

HJ Sake, A Frenzel, A Lucas‐Hahn… - …, 2019 - Wiley Online Library
Background Despite major improvements in pig‐to‐primate xenotransplantation, long‐term
survival of xenografts is still challenging. The major histocompatibility complex (MHC) class I, …