We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

… Joanna S Fowler, PhD Joanna S Fowler … Joanna Fowler was the principal investigator
of the study, responsible for radiochemistry, and wrote the paper. …

Understanding the changes in the brain which occur in the transition from normal to addictive
behavior has major implications in public health. Here we postulate that while reward …

The distribution volume ratio (DVR), which is a linear function of receptor availability, is widely
used as a model parameter in imaging studies. The DVR corresponds to the ratio of the …

A graphical method of analysis applicable to ligands that bind reversibly to receptors or
enzymes requiring the simultaneous measurement of plasma and tissue radioactivities for …

The ability of drugs of abuse to increase dopamine in nucleus accumbens underlies their
reinforcing effects. However, preclinical studies have shown that with repeated drug exposure …

Imaging studies have revealed neurochemical and functional changes in the brains of drug-addicted
subjects that provide new insights into the mechanisms underlying addiction. …

The involvement of dopamine in drug reinforcement is well recognized but its role in drug
addiction is much less clear. Imaging studies have shown that the reinforcing effects of drugs of …

Decreased dopaminergic function has been postulated to underlie cocaine addiction. To
examine the possibility that dysfunction of brain regions subserved by the dopamine system …

OBJECTIVE: The role of dopamine in the addictive process (loss of control and compulsive
drug intake) is poorly understood. A consistent finding in drug-addicted subjects is a lower …