Resveratrol suppresses cancer cell glucose uptake by targeting reactive oxygen species–mediated hypoxia-inducible factor-1α activation
KH Jung, JH Lee, CHT Quach, JY Paik… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Resveratrol is gaining attention for its anticancer effects and is also recognized for its antioxidant
properties and influence on glucose metabolism. Augmented reactive oxygen species (…
properties and influence on glucose metabolism. Augmented reactive oxygen species (…
Oxidized low-density lipoprotein stimulates macrophage 18F-FDG uptake via hypoxia-inducible factor-1α activation through Nox2-dependent reactive oxygen species …
SJ Lee, CHT Quach, KH Jung, JY Paik… - Journal of Nuclear …, 2014 - Soc Nuclear Med
For 18 F-FDG PET to be widely used to monitor atherosclerosis progression and therapeutic
response, it is crucial to better understand how macrophage glucose metabolism is …
response, it is crucial to better understand how macrophage glucose metabolism is …
Effects of anesthetic agents and fasting duration on 18F-FDG biodistribution and insulin levels in tumor-bearing mice
KH Lee, BH Ko, JY Paik, KH Jung… - Journal of Nuclear …, 2005 - Soc Nuclear Med
Small-animal PET has opened the way for imaging 18 F-FDG uptake in murine tumor
models, but the need for anesthesia raises concern over its potential influence on 18 F-FDG …
models, but the need for anesthesia raises concern over its potential influence on 18 F-FDG …
Augmented 18F-FDG uptake in activated monocytes occurs during the priming process and involves tyrosine kinases and protein kinase C
Activated monocytes with a high 18 F-FDG accumulation can affect the results of clinical PET
studies. To better understand the mechanisms regulating monocytic 18 F-FDG uptake, we …
studies. To better understand the mechanisms regulating monocytic 18 F-FDG uptake, we …
Reactive oxygen species-driven HIF1α triggers accelerated glycolysis in endothelial cells exposed to low oxygen tension
JY Paik, KH Jung, JH Lee, JW Park, KH Lee - Nuclear Medicine and …, 2017 - Elsevier
Endothelial cells and their metabolic state regulate glucose transport into underlying tissues.
Here, we show that low oxygen tension stimulates human umbilical vein endothelial cell 18 …
Here, we show that low oxygen tension stimulates human umbilical vein endothelial cell 18 …
Favorable biokinetic and tumor-targeting properties of 99mTc-labeled glucosamino RGD and effect of paclitaxel therapy
KH Jung, KH Lee, JY Paik, BH Ko, JS Bae… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Compared with the recent advancements in radiohalogenated Arg-Gly-Asp (RGD) peptides
for α v β 3 -targeted imaging, there has been limited success with 99m Tc-labeled RGD …
for α v β 3 -targeted imaging, there has been limited success with 99m Tc-labeled RGD …
Nitric oxide stimulates 18F-FDG uptake in human endothelial cells through increased hexokinase activity and GLUT1 expression
The endothelium constitutes a functionally active organ critically involved in angiogenesis.
Nitric oxide (NO) is an important regulator of vascular homeostasis and angiogenesis and …
Nitric oxide (NO) is an important regulator of vascular homeostasis and angiogenesis and …
17β-Estradiol augments 18F-FDG uptake and glycolysis of T47D breast cancer cells via membrane-initiated rapid PI3K–Akt activation
BH Ko, JY Paik, KH Jung, KH Lee - Journal of Nuclear Medicine, 2010 - Soc Nuclear Med
Use of 18 F-FDG uptake as a surrogate marker of therapeutic response requires the recognition
of biologic factors that influence cancer cell glucose metabolism. Estrogen is a potent …
of biologic factors that influence cancer cell glucose metabolism. Estrogen is a potent …
α2-Adrenergic agonists including xylazine and dexmedetomidine inhibit norepinephrine transporter function in SK-N-SH cells
JW Park, HW Chung, EJ Lee, KH Jung, JY Paik… - Neuroscience …, 2013 - Elsevier
α 2 -Adrenergic agonists simulate norepinephrine (NE) action on α 2 receptors of sympathetic
neurons to mediate feedback inhibition of NE release. These agents are used as valuable …
neurons to mediate feedback inhibition of NE release. These agents are used as valuable …
Mitogen-activated protein kinase signaling enhances sodium iodide symporter function and efficacy of radioiodide therapy in nonthyroidal cancer cells
KH Jung, JY Paik, BH Ko, KH Lee - Journal of Nuclear Medicine, 2008 - Soc Nuclear Med
Although the success of sodium/iodide symporter (NIS) gene–based cancer therapy is critically
dependent on the level of radioiodide accumulation attained, recent evidence indicates …
dependent on the level of radioiodide accumulation attained, recent evidence indicates …