Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study
Endocannabinoids and their attending cannabinoid type 1 (CB 1) receptor have been implicated
in animal models of post-traumatic stress disorder (PTSD). However, their specific role …
in animal models of post-traumatic stress disorder (PTSD). However, their specific role …
Assessing synaptic density in Alzheimer disease with synaptic vesicle glycoprotein 2A positron emission tomographic imaging
…, T Toyonaga, S Lin, S Najafzadeh, J Ropchan… - JAMA …, 2018 - jamanetwork.com
Importance Synaptic loss is well established as the major structural correlate of cognitive
impairment in Alzheimer disease (AD). The ability to measure synaptic density in vivo could …
impairment in Alzheimer disease (AD). The ability to measure synaptic density in vivo could …
Rapid changes in cannabinoid 1 receptor availability in cannabis-dependent male subjects after abstinence from cannabis
…, MD Normandin, M Kapinos, J Ropchan… - Biological psychiatry …, 2016 - Elsevier
Background The widespread use of cannabis, the increasing legalization of “medical”
cannabis, the increasing potency of cannabis, and the growing recreational use of synthetic …
cannabis, the increasing potency of cannabis, and the growing recreational use of synthetic …
Synaptic changes in Parkinson disease assessed with in vivo imaging
…, M Dias, S Henry, B Pittman, J Ropchan… - Annals of …, 2020 - Wiley Online Library
Objective Parkinson disease is characterized by motor and nonmotor symptoms, reduced
striatal dopamine signaling, and loss of dopamine neurons in the substantia nigra. It is now …
striatal dopamine signaling, and loss of dopamine neurons in the substantia nigra. It is now …
PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)‐[11C]O‐methylreboxetine and HRRT
…, JD Gallezot, N Nabulsi, D Labaree, J Ropchan… - Synapse, 2010 - Wiley Online Library
Objectives: The role of the norepinephrine transporter (NET) in cocaine dependence has
never been demonstrated via in vivo imaging due to the lack of suitable NET radioligands. …
never been demonstrated via in vivo imaging due to the lack of suitable NET radioligands. …
Recovery from chronic spinal cord contusion after Nogo receptor intervention
…, RE Carson, D Weinzimmer, J Ropchan… - Annals of …, 2011 - Wiley Online Library
Objective: Several interventions promote axonal growth and functional recovery when initiated
shortly after central nervous system injury, including blockade of myelin‐derived inhibitors …
shortly after central nervous system injury, including blockade of myelin‐derived inhibitors …
[HTML][HTML] Association of Aβ deposition and regional synaptic density in early Alzheimer's disease: a PET imaging study with [11C]UCB-J
…, VL Kominek, W Zhao, NB Nabulsi, J Ropchan… - Alzheimer's Research & …, 2021 - Springer
Background Attempts to associate amyloid-β (Aβ) pathogenesis with synaptic loss in
Alzheimer’s disease (AD) have thus far been limited to small numbers of postmortem studies. Aβ …
Alzheimer’s disease (AD) have thus far been limited to small numbers of postmortem studies. Aβ …
Assessment of a white matter reference region for 11C-UCB-J PET quantification
11 C-UCB-J is a positron emission tomography (PET) radioligand that has been used in
humans for synaptic vesicle glycoprotein 2A (SV2A) imaging and as a potential synaptic density …
humans for synaptic vesicle glycoprotein 2A (SV2A) imaging and as a potential synaptic density …
Clinical doses of atomoxetine significantly occupy both norepinephrine and serotonin transports: Implications on treatment of depression and ADHD
Background Atomoxetine (ATX), a drug for treatment of depression and ADHD, has a high
affinity for the norepinephrine transporter (NET); however, our previous study showed it had a …
affinity for the norepinephrine transporter (NET); however, our previous study showed it had a …
Imaging the Cannabinoid CB1 Receptor in Humans with [11C] OMAR: Assessment of Kinetic Analysis Methods, Test–Retest Reproducibility, and Gender Differences
The Radiotracer [ 11 C]OMAR was developed for positron emission tomography (PET)
imaging of cannabinoid type-1 receptors (CB1R). The objectives of the present study were to …
imaging of cannabinoid type-1 receptors (CB1R). The objectives of the present study were to …