[HTML][HTML] Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
…, J Yu, S Costinean, H Kutay, L Yu… - The Journal of …, 2012 - Am Soc Clin Investig
miR-122, an abundant liver-specific microRNA (miRNA), regulates cholesterol metabolism
and promotes hepatitis C virus (HCV) replication. Reduced miR-122 expression in …
and promotes hepatitis C virus (HCV) replication. Reduced miR-122 expression in …
The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation
N 6 -Methyladenosine (m 6 A) is the most abundant RNA modification in mammal mRNAs
and increasing evidence suggests the key roles of m 6 A in human tumorigenesis. However, …
and increasing evidence suggests the key roles of m 6 A in human tumorigenesis. However, …
[HTML][HTML] An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma
…, B Kaur, M Feng, MA Caligiuri, J Yu - Nature …, 2021 - nature.com
Oncolytic herpes simplex virus-1 is capable of lysing tumor cells while alerting the immune
system. CD47, in collaboration with SIRPα, represents an important immune checkpoint to …
system. CD47, in collaboration with SIRPα, represents an important immune checkpoint to …
The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti–PD-1 antibody
…, B Becknell, RA Baiocchi, J Zhang, J Yu… - Blood, The Journal …, 2010 - ashpublications.org
T-cell expression of programmed death receptor-1 (PD-1) down-regulates the immune
response against malignancy by interacting with cognate ligands (eg, PD-L1) on tumor cells; …
response against malignancy by interacting with cognate ligands (eg, PD-L1) on tumor cells; …
[PDF][PDF] The broad spectrum of human natural killer cell diversity
AG Freud, BL Mundy-Bosse, J Yu, MA Caligiuri - Immunity, 2017 - cell.com
Natural killer (NK) cells provide protection against infectious pathogens and cancer. For
decades it has been appreciated that two major NK cell subsets (CD56 bright and CD56 dim ) …
decades it has been appreciated that two major NK cell subsets (CD56 bright and CD56 dim ) …
[HTML][HTML] Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
…, J Chu, M Namaka, T Hughes, L Ye, J Yu… - Nature …, 2018 - nature.com
The metabolic checkpoint kinase mechanistic/mammalian target of rapamycin (mTOR) regulates
natural killer (NK) cell development and function, but the exact underlying mechanisms …
natural killer (NK) cell development and function, but the exact underlying mechanisms …
MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and …
…, E Callegari, S Schwind, J Pang, J Yu… - Blood, The Journal …, 2009 - ashpublications.org
Aberrant DNA hypermethylation contributes to myeloid leukemogenesis by silencing structurally
normal genes involved in hematopoiesis. MicroRNAs (miRNAs) are noncoding RNAs …
normal genes involved in hematopoiesis. MicroRNAs (miRNAs) are noncoding RNAs …
CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma
…, X Zhang, MA Caligiuri, CC Hofmeister, J Yu - Leukemia, 2014 - nature.com
Multiple myeloma (MM) is an incurable hematological malignancy. Chimeric antigen receptor
(CAR)-expressing T cells have been demonstrated successfully in the clinic to treat B-…
(CAR)-expressing T cells have been demonstrated successfully in the clinic to treat B-…
Location and cellular stages of natural killer cell development
J Yu, AG Freud, MA Caligiuri - Trends in immunology, 2013 - cell.com
The identification of distinct tissue-specific natural killer (NK) cell populations that apparently
mature from local precursor populations has brought new insight into the diversity and …
mature from local precursor populations has brought new insight into the diversity and …
Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses
…, D Gianni, K Kurozomi, SS Rhee, J Yu… - Proceedings of the …, 2006 - National Acad Sciences
Clinical trials are testing oncolytic viruses (OVs) as therapies for cancer. We have shown
that animals that have brain tumors and are treated with a herpes simplex virus (HSV)-derived …
that animals that have brain tumors and are treated with a herpes simplex virus (HSV)-derived …