The mitochondrial inner membrane contains a large protein complex that functions in inner
membrane organization and formation of membrane contact sites. The complex was variably …

The enantioselective synthesis of endothelin-A antagonist ABT-546 has been accomplished
via the discovery and development of a highly selective catalytic asymmetric conjugate …

Development of new methods for the preparation of enantiomerically pure compounds is an
important goal for synthesis. There are numerous examples of enantioselective Diels-Alder, …

End resection in homologous recombination (HR) and HR-mediated repair of DNA double-strand
breaks (DSBs) removes several kilobases from 5′ strands of DSBs, but 3′ strands …

When replication forks stall at damaged bases or upon nucleotide depletion, the intra-S
phase checkpoint ensures they are stabilized and can restart. In intra-S checkpoint-deficient …

Non-homologous end joining (NHEJ) is a major pathway to repair DNA double-strand breaks
(DSBs), which can display different types of broken ends. However, it is unclear how NHEJ …

Microcystins (MCs) are a family of cyclic heptapeptide hepatotoxins produced by freshwater
species of cyanobacteria that have been implicated in the development of liver cancer, …

Tumor-associated macrophages are increasingly viewed as a target of great relevance in
the tumor microenvironment, because of their important role in cancer progression and …

Microglia play a pivotal role in clearance of Aβ by degrading them in lysosomes, countering
amyloid plaque pathogenesis in Alzheimer's disease (AD). Recent evidence suggests that …

Aims: Parkinson's disease (PD) heavily affects humans and little is known about its cause
and pathogenesis. Sirtuin 3 (Sirt3) plays a key role in regulating mitochondrial dysfunction, …