Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance

W Wu, JL Klockow, M Zhang, F Lafortune… - Pharmacological …, 2021 - Elsevier
Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …

Three-input logic gates with potential applications for neuronal imaging

KS Hettie, JL Klockow, TE Glass - Journal of the American …, 2014 - ACS Publications
Convenient methods for the direct visualization of neurotransmitter trafficking would bolster
investigations into the development of neurodegenerative diseases. Here, tunable …

A Novel Theranostic Strategy for MMP-14–Expressing Glioblastomas Impacts Survival

S Mohanty, Z Chen, K Li, GR Morais, J Klockow… - Molecular cancer …, 2017 - AACR
Glioblastoma (GBM) has a dismal prognosis. Evidence from preclinical tumor models and
human trials indicates the role of GBM-initiating cells (GIC) in GBM drug resistance. Here, we …

An activatable NIR fluorescent rosol for selectively imaging nitroreductase activity

JL Klockow, KS Hettie, EL LaGory, EJ Moon… - Sensors and Actuators B …, 2020 - Elsevier
Hypoxia (ie, pO 2 ≤ ∼1.5 %) is an important characteristic of tumor microenvironments that
directly correlates with resistance against first-line therapies and tumor proliferation/…

Development of a Fluorescent Chemosensor for the Detection of Kynurenine

JL Klockow, TE Glass - Organic letters, 2013 - ACS Publications
Kynurenine, a metabolite of tryptophan, is known to contribute to cancer progression when
overproduced. A method for facile fluorescent sensing of kynurenine using sensor 1 has been …

Discovery of a CSF-1R inhibitor and PET tracer for imaging of microglia and macrophages in the brain

B Van Der Wildt, JL Klockow, Z Miao, ST Reyes… - Nuclear medicine and …, 2022 - Elsevier
Colony stimulating factor 1 receptor (CSF-1R) is a kinase expressed on macrophages and
microglia in the brain. It has been recognized as a potential drug and imaging target in …

ExoSensor 517: a dual-analyte fluorescent chemosensor for visualizing neurotransmitter exocytosis

JL Klockow, KS Hettie, TE Glass - ACS chemical neuroscience, 2013 - ACS Publications
A dual-analyte fluorescent chemosensor (ExoSensor 517) for the direct visualization of
neurotransmitters released upon exocytosis is presented. The sensor exploits the high …

BLZ945 derivatives for PET imaging of colony stimulating factor-1 receptors in the brain

…, Z Miao, ST Reyes, JH Park, JL Klockow… - Nuclear medicine and …, 2021 - Elsevier
Background The kinase colony stimulating factor-1 receptor (CSF-1R) has recently been
identified as a novel therapeutic target for decreasing tumor associated macrophages and …

Reactive oxygen species and enzyme dual-responsive biocompatible drug delivery system for targeted tumor therapy

N Zhao, B Ding, Y Zhang, JL Klockow, K Lau… - Journal of controlled …, 2020 - Elsevier
Spurred by newly developed drug delivery systems (DDSs), side effects of cancer chemotherapy
could be reduced by using multifunctional nanoplatforms. However, the facile synthesis …

[HTML][HTML] Theranostic nanoparticles enhance the response of glioblastomas to radiation

W Wu, JL Klockow, S Mohanty, KS Ku, M Aghighi… - …, 2019 - ncbi.nlm.nih.gov
Despite considerable progress with our understanding of glioblastoma multiforme (GBM) and
the precise delivery of radiotherapy, the prognosis for GBM patients is still unfavorable with …