Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance
Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …
Three-input logic gates with potential applications for neuronal imaging
Convenient methods for the direct visualization of neurotransmitter trafficking would bolster
investigations into the development of neurodegenerative diseases. Here, tunable …
investigations into the development of neurodegenerative diseases. Here, tunable …
A Novel Theranostic Strategy for MMP-14–Expressing Glioblastomas Impacts Survival
Glioblastoma (GBM) has a dismal prognosis. Evidence from preclinical tumor models and
human trials indicates the role of GBM-initiating cells (GIC) in GBM drug resistance. Here, we …
human trials indicates the role of GBM-initiating cells (GIC) in GBM drug resistance. Here, we …
An activatable NIR fluorescent rosol for selectively imaging nitroreductase activity
Hypoxia (ie, pO 2 ≤ ∼1.5 %) is an important characteristic of tumor microenvironments that
directly correlates with resistance against first-line therapies and tumor proliferation/…
directly correlates with resistance against first-line therapies and tumor proliferation/…
Development of a Fluorescent Chemosensor for the Detection of Kynurenine
JL Klockow, TE Glass - Organic letters, 2013 - ACS Publications
Kynurenine, a metabolite of tryptophan, is known to contribute to cancer progression when
overproduced. A method for facile fluorescent sensing of kynurenine using sensor 1 has been …
overproduced. A method for facile fluorescent sensing of kynurenine using sensor 1 has been …
Discovery of a CSF-1R inhibitor and PET tracer for imaging of microglia and macrophages in the brain
B Van Der Wildt, JL Klockow, Z Miao, ST Reyes… - Nuclear medicine and …, 2022 - Elsevier
Colony stimulating factor 1 receptor (CSF-1R) is a kinase expressed on macrophages and
microglia in the brain. It has been recognized as a potential drug and imaging target in …
microglia in the brain. It has been recognized as a potential drug and imaging target in …
ExoSensor 517: a dual-analyte fluorescent chemosensor for visualizing neurotransmitter exocytosis
A dual-analyte fluorescent chemosensor (ExoSensor 517) for the direct visualization of
neurotransmitters released upon exocytosis is presented. The sensor exploits the high …
neurotransmitters released upon exocytosis is presented. The sensor exploits the high …
BLZ945 derivatives for PET imaging of colony stimulating factor-1 receptors in the brain
…, Z Miao, ST Reyes, JH Park, JL Klockow… - Nuclear medicine and …, 2021 - Elsevier
Background The kinase colony stimulating factor-1 receptor (CSF-1R) has recently been
identified as a novel therapeutic target for decreasing tumor associated macrophages and …
identified as a novel therapeutic target for decreasing tumor associated macrophages and …
Reactive oxygen species and enzyme dual-responsive biocompatible drug delivery system for targeted tumor therapy
N Zhao, B Ding, Y Zhang, JL Klockow, K Lau… - Journal of controlled …, 2020 - Elsevier
Spurred by newly developed drug delivery systems (DDSs), side effects of cancer chemotherapy
could be reduced by using multifunctional nanoplatforms. However, the facile synthesis …
could be reduced by using multifunctional nanoplatforms. However, the facile synthesis …
[HTML][HTML] Theranostic nanoparticles enhance the response of glioblastomas to radiation
Despite considerable progress with our understanding of glioblastoma multiforme (GBM) and
the precise delivery of radiotherapy, the prognosis for GBM patients is still unfavorable with …
the precise delivery of radiotherapy, the prognosis for GBM patients is still unfavorable with …