Purpose: Pyruvate kinase M2 (PKM2) catalyzes the final step in glycolysis, a key process of
cancer metabolism. PKM2 is preferentially expressed by glioblastoma (GBM) cells with …

Positron emission tomography (PET) imaging of apoptosis can noninvasively detect cell
death in vivo and assist in monitoring tumor response to treatment in patients. While extensive …

Fragile X syndrome (FXS), a disorder of synaptic development and function, is the most
prevalent genetic form of intellectual disability and autism spectrum disorder. FXS mouse models …

The aim of this study was development of an improved PET radiotracer for measuring x C −
activity with increased tumor uptake and reduced uptake in inflammatory cells compared with …

This study defines MetAP2 as an early-risk stratifier for molecular imaging of aggressive
prostate cancer and describes a MetAP2-activated self-assembly small-molecule PET tracer for …

Introduction: Chronic pelvic pain is a highly prevalent pain condition among women, but
identifying the exact cause of pelvic pain remains a significant diagnostic challenge. In this study…

Purpose Innate immune activation plays a critical role in the onset and progression of many
diseases. While positron emission tomography (PET) imaging provides a non-invasive …

Background ANAVEX® 2-73, a selective sigma-1 receptor (S1R) agonist, has undergone
testing in a Phase 2a trial of Alzheimer's disease patients. Over a period of 57 weeks, ANAVEX…

Background Measurement of the spatial distribution of Tau pathology is critical for early
diagnosis and disease monitoring. We sought to investigate a novel Tau PET ligand, 18 F-PI2620…

Background Primary pathology of Alzheimer disease (AD) includes both β-amyloid and
neurofibrillary tangles (NFT) of misfolded tau. Diagnosing tau pathology in vivo and correlating …