Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by
a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic …

Purpose Pathological studies suggest that neuroinflammation is exacerbated by increased
beta-amyloid (Aβ) levels in the brain early in Alzheimer’s disease (AD). The time course and …

nanoScan is a high-resolution integrated system for consecutive PET and MR imaging of
small laboratory animals. We evaluated the performance of the system, using the NEMA NU 4-…

Huntington's disease (HD) symptoms are driven to a large extent by dysfunction of the basal
ganglia circuitry. HD patients exhibit reduced striatal phoshodiesterase 10 (PDE10) levels. …

Adequate estimation of neuroinflammatory processes following ischemic stroke is essential
for better understanding of disease mechanisms, and for the development of treatment …

Amphetamine produces its rewarding effects by enhancing dopamine transmission in the
mesocorticolimbic pathway. Several studies have also suggested the involvement of the …

Molecular imaging of the 18 kD Translocator protein (TSPO) with positron emission
tomography (PET) is of great value for studying neuroinflammation in rodents longitudinally. …

Whereas amphetamine and other psychostimulants primarily act on the dopamine system,
there is also evidence that other neurotransmitter systems, such as the endogenous opioid …

We present the first results of the MINDVIEW project. An innovative imaging system for the
human brain examination, allowing simultaneous acquisition of PET/MRI images, has been …

Amphetamine, and other stimulants, readily induces behavioral sensitization, an effect
hypothesized to reflect neurobiological changes that may underlie certain aspects of drug …