Solution-phase surface modification in intact poly (dimethylsiloxane) microfluidic channels
…, J Wang, CC Lee, W Lu, SP Lee, JV Leyton… - Analytical …, 2006 - ACS Publications
An improved approach composed of an oxidation reaction in acidic H 2 O 2 solution and a
sequential silanization reaction using neat silane reagents for surface modification of poly(…
sequential silanization reaction using neat silane reagents for surface modification of poly(…
Nuclear localization signal-tagged systems: Relevant nuclear import principles in the context of current therapeutic design
…, G Coulombe, D Patel, VM Rotello, JV Leyton - Chemical Society …, 2024 - pubs.rsc.org
Nuclear targeting of therapeutics provides a strategy for enhancing efficacy of molecules
active in the nucleus and minimizing off-target effects. ‘Active’ nuclear-directed transport and …
active in the nucleus and minimizing off-target effects. ‘Active’ nuclear-directed transport and …
[HTML][HTML] Antibody therapies for acute myeloid leukemia: unconjugated, toxin-conjugated, radio-conjugated and multivalent formats
…, A Law, J Hunyadkurti, S Desilets, JV Leyton… - Journal of clinical …, 2019 - mdpi.com
In recent decades, therapy for acute myeloid leukemia (AML) has remained relatively unchanged,
with chemotherapy regimens primarily consisting of an induction regimen based on a …
with chemotherapy regimens primarily consisting of an induction regimen based on a …
[HTML][HTML] Targeted molecular therapeutics for bladder cancer—a new option beyond the mixed fortunes of immune checkpoint inhibitors?
O Bednova, JV Leyton - International journal of molecular sciences, 2020 - mdpi.com
The fact that there are now five immune checkpoint inhibitor (ICI) monoclonal antibodies
approved since 2016 that target programmed cell death protein 1 or programmed death ligand-…
approved since 2016 that target programmed cell death protein 1 or programmed death ligand-…
Humanized radioiodinated minibody for imaging of prostate stem cell antigen–expressing tumors
JV Leyton, T Olafsen, EJ Lepin, S Hahm, KB Bauer… - Clinical Cancer …, 2008 - AACR
Purpose: Prostate stem cell antigen (PSCA) is a cell surface glycoprotein that is overexpressed
in prostate cancer, including hormone refractory disease. Previous preclinical studies …
in prostate cancer, including hormone refractory disease. Previous preclinical studies …
Targeting, imaging, and therapy using a humanized antiprostate stem cell antigen (PSCA) antibody
T Olafsen, Z Gu, MA Sherman, JV Leyton… - Journal of …, 2007 - journals.lww.com
The murine 1G8 (mu1G8) monoclonal antibody directed against prostate stem cell antigen (PSCA)
prevents prostate tumor establishment, growth, and metastasis in murine models. To …
prevents prostate tumor establishment, growth, and metastasis in murine models. To …
[HTML][HTML] An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors
EJ Lepin, JV Leyton, Y Zhou, T Olafsen… - European journal of …, 2010 - Springer
Purpose Prostate stem cell antigen (PSCA), a cell surface glycoprotein expressed in normal
human prostate and bladder, is over-expressed in the majority of localized prostate cancer …
human prostate and bladder, is over-expressed in the majority of localized prostate cancer …
[HTML][HTML] Impact of endocytosis mechanisms for the receptors targeted by the currently approved antibody-drug conjugates (ADCS)—A necessity for future adc research …
M Hammood, AW Craig, JV Leyton - Pharmaceuticals, 2021 - mdpi.com
Biologically-based therapies increasingly rely on the endocytic cycle of internalization and
exocytosis of target receptors for cancer therapies. However, receptor trafficking pathways (…
exocytosis of target receptors for cancer therapies. However, receptor trafficking pathways (…
111In-Bn-DTPA-nimotuzumab with/without modification with nuclear translocation sequence (NLS) peptides: an Auger electron-emitting radioimmunotherapeutic …
Increased expression of epidermal growth factor receptors (EGFR) in breast cancer (BC) is
often associated with trastuzumab (Herceptin)-resistant forms of the disease and represents …
often associated with trastuzumab (Herceptin)-resistant forms of the disease and represents …
Engineered humanized diabodies for microPET imaging of prostate stem cell antigen-expressing tumors
JV Leyton, T Olafsen, MA Sherman… - … , Design & Selection, 2009 - academic.oup.com
We have previously demonstrated preclinical in vivo targeting of prostate stem cell antigen (PSCA)
using a humanized anti-PSCA 2B3 monoclonal antibody (mAb). However, …
using a humanized anti-PSCA 2B3 monoclonal antibody (mAb). However, …