Solution-phase surface modification in intact poly (dimethylsiloxane) microfluidic channels

…, J Wang, CC Lee, W Lu, SP Lee, JV Leyton… - Analytical …, 2006 - ACS Publications
An improved approach composed of an oxidation reaction in acidic H 2 O 2 solution and a
sequential silanization reaction using neat silane reagents for surface modification of poly(…

Nuclear localization signal-tagged systems: Relevant nuclear import principles in the context of current therapeutic design

…, G Coulombe, D Patel, VM Rotello, JV Leyton - Chemical Society …, 2024 - pubs.rsc.org
Nuclear targeting of therapeutics provides a strategy for enhancing efficacy of molecules
active in the nucleus and minimizing off-target effects. ‘Active’ nuclear-directed transport and …

[HTML][HTML] Antibody therapies for acute myeloid leukemia: unconjugated, toxin-conjugated, radio-conjugated and multivalent formats

…, A Law, J Hunyadkurti, S Desilets, JV Leyton… - Journal of clinical …, 2019 - mdpi.com
In recent decades, therapy for acute myeloid leukemia (AML) has remained relatively unchanged,
with chemotherapy regimens primarily consisting of an induction regimen based on a …

[HTML][HTML] Targeted molecular therapeutics for bladder cancer—a new option beyond the mixed fortunes of immune checkpoint inhibitors?

O Bednova, JV Leyton - International journal of molecular sciences, 2020 - mdpi.com
The fact that there are now five immune checkpoint inhibitor (ICI) monoclonal antibodies
approved since 2016 that target programmed cell death protein 1 or programmed death ligand-…

Humanized radioiodinated minibody for imaging of prostate stem cell antigen–expressing tumors

JV Leyton, T Olafsen, EJ Lepin, S Hahm, KB Bauer… - Clinical Cancer …, 2008 - AACR
Purpose: Prostate stem cell antigen (PSCA) is a cell surface glycoprotein that is overexpressed
in prostate cancer, including hormone refractory disease. Previous preclinical studies …

Targeting, imaging, and therapy using a humanized antiprostate stem cell antigen (PSCA) antibody

T Olafsen, Z Gu, MA Sherman, JV Leyton… - Journal of …, 2007 - journals.lww.com
The murine 1G8 (mu1G8) monoclonal antibody directed against prostate stem cell antigen (PSCA)
prevents prostate tumor establishment, growth, and metastasis in murine models. To …

[HTML][HTML] An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors

EJ Lepin, JV Leyton, Y Zhou, T Olafsen… - European journal of …, 2010 - Springer
Purpose Prostate stem cell antigen (PSCA), a cell surface glycoprotein expressed in normal
human prostate and bladder, is over-expressed in the majority of localized prostate cancer …

[HTML][HTML] Impact of endocytosis mechanisms for the receptors targeted by the currently approved antibody-drug conjugates (ADCS)—A necessity for future adc research …

M Hammood, AW Craig, JV Leyton - Pharmaceuticals, 2021 - mdpi.com
Biologically-based therapies increasingly rely on the endocytic cycle of internalization and
exocytosis of target receptors for cancer therapies. However, receptor trafficking pathways (…

111In-Bn-DTPA-nimotuzumab with/without modification with nuclear translocation sequence (NLS) peptides: an Auger electron-emitting radioimmunotherapeutic …

A Fasih, H Fonge, Z Cai, JV Leyton, I Tikhomirov… - Breast cancer research …, 2012 - Springer
Increased expression of epidermal growth factor receptors (EGFR) in breast cancer (BC) is
often associated with trastuzumab (Herceptin)-resistant forms of the disease and represents …

Engineered humanized diabodies for microPET imaging of prostate stem cell antigen-expressing tumors

JV Leyton, T Olafsen, MA Sherman… - … , Design & Selection, 2009 - academic.oup.com
We have previously demonstrated preclinical in vivo targeting of prostate stem cell antigen (PSCA)
using a humanized anti-PSCA 2B3 monoclonal antibody (mAb). However, …