In vitro Cytotoxicity of Epigallocatechin Gallate and Tea Extracts to Cancerous and Normal Cells from the Human Oral Cavity

JH Weisburg, DB Weissman… - Basic & clinical …, 2004 - Wiley Online Library
This study compared the in vitro responses of malignant and normal cells from the human oral
cavity to tea extracts and to its main polyphenolic component, (−)‐epigallocatechin gallate …

[HTML][HTML] Research strategies in the study of the pro-oxidant nature of polyphenol nutraceuticals

H Babich, AG Schuck, JH Weisburg… - Journal of …, 2011 - hindawi.com
Polyphenols of phytochemicals are thought to exhibit chemopreventive effects against
cancer. These plant-derived antioxidant polyphenols have a dual nature, also acting as pro-…

Ellagic acid, a dietary polyphenol, selectively cytotoxic to HSC-2 oral carcinoma cells

JH Weisburg, AG Schuck, SE Reiss, BJ Wolf… - Anticancer …, 2013 - ar.iiarjournals.org
Background: The antiproliferative and apoptotic effects of ellagic acid, a dietary polyphenol,
were studied. Materials and Methods: The neutral red cytotoxicity assay compared the …

The multidrug resistance phenotype confers immunological resistance.

JH Weisburg, M Curcio, PC Caron, G Raghu… - The Journal of …, 1996 - rupress.org
Multidrug resistance (MDR), which is due, in part, to the overexpression of P-glycoprotein,
confers resistance to a variety of natural product chemotherapeutic agents such as …

[HTML][HTML] Intracellular pH and multidrug resistance regulate complement-mediated cytotoxicity of nucleated human cells

JH Weisburg, PD Roepe, S Dzekunov… - Journal of Biological …, 1999 - ASBMB
… To examine if Cl − /HCO 3 − exchanger function was involved in any resistance to complement
when the cells were suspended in Cl − -free HBSS, cells were treated with H 2 DIDS prior …

Pomegranate extract, a prooxidant with antiproliferative and proapoptotic activities preferentially towards carcinoma cells

JH Weisburg, AG Schuck… - Anti-Cancer Agents …, 2010 - ingentaconnect.com
The antiproliferative and proapoptotic effects of pomegranate extract (PE), as correlated
with its prooxidant activity, were studied. PE exerted greater antiproliferative effects towards …

Multidrug resistance in acute myeloid leukemia: potential new therapeutics

JH Weisburg - Journal of Nuclear Medicine, 2008 - Soc Nuclear Med
In acute myeloid leukemias (AMLs), multidrug resistance (MDR) is frequently, but not always,
caused by the MDR1 gene product, a 170-to 180-kDa glycoprotein known as P-…

Differential expression patterns of SUMO proteins in HL-60 cancer cell lines support a role for sumoylation in the development of drug resistance

M Vigodner, JH Weisburg, V Shrivastava… - Cell and tissue …, 2009 - Springer
Small ubiquitin-like modifier (SUMO) proteins are involved in a variety of cellular processes.
Alterations in SUMO conjugation have been implicated in several human diseases, …

[BOOK][B] Multidrug resistance, intracellular pH (pH (i), and the regulation of immune-based cytotoxicity

JH Weisburg - 1998 - search.proquest.com
… In 1993, Jeffrey was married to Jessica L Israel, whom he had met at Clark University. Also
that … In September 1997, Jeffrey's wife gave birth to their first child- a boy named Benjamin. …

Novel Cl--dependent intracellular pH regulation in murine MDR 1 transfectants and potential implications

PD Roepe, JH Weisburg, JG Luz, MM Hoffman… - Biochemistry, 1994 - ACS Publications
… of H+ flux at different pH¡ shows that Ch-dependent reacidification approaches 0.2 mM H+/s …
an alternate route for slower "HCOs entry or H+ exit that is somehow linked to the activation …