The β emitting isotopes 186 Re and 188 Re are logical choices on which to base
therapeutic radiopharmaceuticals that might be expected to be analogous to diagnostic …

Background— Apoptosis is common in advanced human atheroma and contributes to
plaque instability. Because annexin V has a high affinity for exposed phosphatidylserine on …

This review provides a critical and thorough overview of the radiopharmaceutical development
and in vivo evaluation of all apoptosis-detecting radioligands that have emerged so far, …

99m Tc-hydrazinonicotinamido (HYNIC)-annexin V is a novel tracer for in vivo imaging of
apoptosis. The present study on humans was performed to investigate the safety of 99m Tc-…

Purpose: Radiolabeled annexin V may allow for repetitive and selective in vivo identification
of apoptotic cell death without the need for invasive biopsy. This study reports on the …

Anthracyclines are widely used in chemotherapy regimens for several malignancies, with
cardiotoxicity being the major limiting factor in high-dose schedules. Recently, it was reported …

Labeled annexin V is widely used to detect cell death in vitro and in vivo. Nearly all studies
have been done with annexin V derivatized via amine-directed bifunctional agents; it was …

Purpose 99m Tc-Annexin A5 has been used as a molecular imaging probe for the visualization,
characterization and measurement of apoptosis. In an effort to define the quantitative …

As positron emission tomography (PET) imaging is becoming more prevalent in clinical
practice, it is reasonable to ask if there will be a role for single photon emission computed …

Purpose The first aim of the study was to determine whether 99m Tc-HYNIC-annexin V, a
marker of cellular stress and apoptosis, can detect ischemic injury in patients with acute stroke. …