Purpose The PET tracer 82 Rb is commonly used to evaluate regional perfusion defects for
the diagnosis of coronary artery disease. There is limited information on the quantification of …

OBJECTIVE: Dysfunctional attitudes are negatively biased assumptions and beliefs
regarding oneself, the world, and the future. In healthy subjects, increasing serotonin (5-HT) …

Log P measurements are a fundamental physico-chemical parameter and one of the cornerstones
of structure–activity relationships in medicinal chemistry. Despite the attractiveness of …

Background— Heart failure with reduced ejection fraction and obstructive sleep apnea (OSA),
2 states of increased metabolic demand and sympathetic nervous system activation, often …

Background— Whether viability imaging can impact long-term patient outcomes is uncertain.
The PARR-2 study (Positron Emission Tomography and Recovery Following …

Aims We investigated the role of metabolic alterations in the development of a maladaptive
right ventricular (RV) response in pulmonary arterial hypertension (PAH), which has not …

Background— Left heart failure is characterized by alterations in metabolic substrate utilization,
and metabolic modulation may be a future strategy in the management of heart failure. …

Objectives : We sought to examine the short-term and longer term (6-week) effects of continuous
positive airway pressure (CPAP) on myocardial energetics. Background : Obstructive …

Background Diabetes mellitus is strongly associated with cardiovascular dysfunction, derived
in part from impairment of sympathetic nervous system signaling. Glucose, insulin, and non…

Background Diagnosis of coronary disease and microvascular dysfunction may be improved
by comparing myocardial perfusion scans with a database defining the lower limit of normal …