Macular degeneration is hallmarked by retinal accumulation of toxic retinoid species (eg.,
A2E) for which there is no endogenous mechanism to eliminate it. This ultimately results in …

Type 1 diabetes (T1D) is characterized by the autoimmune-mediated attack of insulin-producing
beta cells in the pancreas, leading to reliance on exogenous insulin to control a patient’…

Vitamin A based bisretinoid accumulation is a major focus in the study of macular
degeneration. Whether specific endogenous lysosomal proteins can bind A2E, a pronounced …

Saposin B (SapB) is a human lysosomal protein, critical for the degradation of O-sulfogalactosylceramide
(sulfatide). SapB binds sulfatide and presents it to the active site of the enzyme …

1074 Objectives: Monoclonal antibody-based immunotherapeutics are a promising class of
targeted anti-cancer drugs due to their high target specificity. These characteristics also …

This thesis seeks to address the binding behavior and functionality of the lysosomal
sphingolipid activator protein saposin B (sapB). SapB is critical for the degradation of O-…

The Front Cover picture illustrates lipofuscin bisretinoid A2E blue-light-induced photooxidation
and its protection by the lysosomal protein Saposin B (SapB). Binding of A2E, a common …

… Jay Tinklepaugh for assistance with the acquisition of radioTLC images and for supplying
the independent data set with which the statistical model was validated. The authors would …

… Jay Tinklepaugh for assistance with the acquisition of radioTLC images and for supplying
the independent data set with which the statistical model was validated. The authors would …

There is considerable inter-generic and inter-specific variation in the mode and quality of
the mother-infant relationship. Although the Nilgiri langur mother-infant dyad resembles that …