User profiles for Jason Kovacic

Jason C Kovacic | MBBS, PhD, FRACP, FACC, FSCAI, FAHA

Victor Chang Cardiac Research Institute
Verified email at victorchang.edu.au
Cited by 13257

[HTML][HTML] Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

…, R Hajjar, V Fuster, M Boehm, JC Kovacic - Nature …, 2016 - nature.com
Endothelial to mesenchymal transition (EndMT) plays a major role during development, and
also contributes to several adult cardiovascular diseases. Importantly, mesenchymal cells …

Epithelial-to-mesenchymal and endothelial-to-mesenchymal transition: from cardiovascular development to disease

JC Kovacic, N Mercader, M Torres, M Boehm… - Circulation, 2012 - Am Heart Assoc
Cellular switching from an epithelial-to-mesenchymal phenotype, and conversely from a
mesenchymal-toepithelial phenotype, are important biological programs that are operative from …

TGF-β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling

…, R Feil, R Virmani, E Ladich, JC Kovacic… - Science translational …, 2014 - science.org
Veins grafted into an arterial environment undergo a complex vascular remodeling process.
Pathologic vascular remodeling often results in stenosed or occluded conduit grafts. …

Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review

JC Kovacic, S Dimmeler, RP Harvey, T Finkel… - Journal of the American …, 2019 - jacc.org
Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell
undergoes a series of molecular events that lead to a change in phenotype toward a …

Cellular senescence, vascular disease, and aging: part 2 of a 2-part review: clinical vascular disease in the elderly

JC Kovacic, P Moreno, EG Nabel, V Hachinski… - Circulation, 2011 - Am Heart Assoc
The increasing prevalence of older-age people in our society represents the culmination of
centuries of medical, scientific, and social endeavors. At least in Western society, now …

Impact of oxidative stress on the heart and vasculature: part 2 of a 3-part series

…, C Maack, NR Bonetti, V Fuster, JC Kovacic - Journal of the American …, 2017 - jacc.org
Vascular disease and heart failure impart an enormous burden in terms of global morbidity
and mortality. Although there are many different causes of cardiac and vascular disease, …

First international consensus on the diagnosis and management of fibromuscular dysplasia

…, D Kadian-Dodov, ESH Kim, JC Kovacic… - Vascular …, 2019 - journals.sagepub.com
This article is a comprehensive document on the diagnosis and management of fibromuscular
dysplasia (FMD), which was commissioned by the working group ‘Hypertension and the …

Oxidative stress and cardiovascular risk: obesity, diabetes, smoking, and pollution: part 3 of a 3-part series

…, MR Miller, DE Newby, V Fuster, JC Kovacic - Journal of the American …, 2017 - jacc.org
Oxidative stress occurs whenever the release of reactive oxygen species (ROS) exceeds
endogenous antioxidant capacity. In this paper, we review the specific role of several …

Colchicine in cardiovascular disease: in-depth review

…, C Arnott, S Patel, M Parsons, JC Tardif, JC Kovacic… - Circulation, 2022 - Am Heart Assoc
Inflammation plays a prominent role in the development of atherosclerosis and other
cardiovascular diseases, and anti-inflammatory agents may improve cardiovascular outcomes. For …

Impact of the everolimus-eluting stent on stent thrombosis: a meta-analysis of 13 randomized trials

…, MC Kim, J Suleman, R Pyo, J Wiley, J Kovacic… - Journal of the American …, 2011 - jacc.org
Objectives : We evaluated the impact of the everolimus-eluting stent (EES) on the frequency
of stent thrombosis (ST), target vessel revascularization (TVR), myocardial infarction (MI), …