Purpose: A multicenter, phase II study of single-agent, intravenous methotrexate in newly
diagnosed non-AIDS-related primary CNS lymphoma was conducted in the New Approaches …

Positron emission tomography (PET) studies have been performed using 18‐F‐fluorodeoxyglucose
in 29 adult subjects with primary brain tumors. Seventy‐two percent of the patients …

In a prospective, controlled, randomized study to evaluate the efficacy of filtration-leukapheresis
granulocytes in granulocytopenic, febrile patients with leukemia, 19 patients received …

The (F-18) fluorodeoxyglucose (FDG) technique to measure local cerebral metabolic rate for
glucose (LCMRglu) is well accepted and widely used by many institutions around the world. …

Penicillamine is an oral agent used to treat intracerebral copper overload in Wilson's disease.
Copper is a known regulator of angiogenesis; copper reduction inhibits experimental …

I. Abstract Primary CNS malignancies are responsible for approximately 12,000 deaths
annually in the United States. There has been little change in the outcome for adults with …

METHODS The study group included: unilateral cerebral infarction— 23 (mean age 65 yr,
range 47-80 yr), unilateral cerebral tumor— 23 (mean age 52 yr, range 37-71 yr), …

BACKGROUND. The prognosis for patients with recurrent high‐grade gliomas is poor and
treatment options are limited. Current chemotherapeutic regimens can improve clinical …

Protein kinase C alpha (PKC-α) is a cytoplasmic serine threonine kinase involved in regulating
cell differentiation and proliferation. Aprinocarsen is an antisense oligonucleotide against …

A 30-yr-old right-handed male noted abnormal sensation in his right foot in 1991. A bone
spur was removed surgically, but there was no symptom relief. A complete clinical and …