White matter lesions, commonly seen on MRIs of elderly people, are related to various geriatric
disorders, including cerebrovascular diseases, cardiovascular diseases, dementia, and …

Background: There is a growing literature on the importance of hippocampal volume in
geriatric depression. Methods: We examined hippocampal volume in a group of elderly …

Diffusion tensor imaging (DTI) measures the displacement of water molecules across tissue
components, thus providing information regarding the microstructure of cerebral white matter…

BACKGROUND: The dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC)
are critical for mood regulation. Alterations in the white matter connections of these …

Context Research on vascular depression has used 2 approaches to subtype late-life
depression, based on executive dysfunction or white matter hyperintensity severity. Objective To …

BACKGROUND: There is a substantial body of research supporting the vascular depression
hypothesis of late-life depression. To update this hypothesis so it incorporates recent …

BackgroundChildhood early life stress (ELS) increases risk of adulthood major depressive
disorder (MDD) and is associated with altered brain structure and function. It is unclear …

Two healthy volunteers who had inhaled approximately 0.75 L of laser-polarized helium-3
gas underwent magnetic resonance imaging at 1.5 T with fast gradient-echo pulse sequences …

Context White matter hyperintensities (WMHs) are bright foci seen in the parenchyma of the
brain on T2-weighted cranial magnetic resonance imaging (MRI) scans and are associated …

OBJECTIVE: The purpose of this study was to determine whether microstructural
abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late-life …