Previously, we demonstrated that ischemia induces mitochondrial damage and dysfunction
that persist throughout reperfusion and impact negatively on postischemic functional …

Mitochondrial damage and dysfunction occur during ischemia and modulate cardiac function
and cell survival significantly during reperfusion. We hypothesized that transplantation of …

Mitochondria play a key role in the homeostasis of the vast majority of the body’s cells. In
the myocardium where mitochondria constitute 30 % of the total myocardial cell volume, …

Materials and Methods Pediatric patients who required central ECMO support for ischemia-reperfusion–associated
myocardial dysfunction after cardiac surgical procedure were eligible …

Kynurenic acid (KynA) is tissue protective in cardiac, cerebral, renal, and retinal ischemia
models, but the mechanism is unknown. KynA can bind to multiple receptors, including the aryl …

Objective To demonstrate the clinical efficacy of autologous mitochondrial transplantation in
preparation for translation to human application using an in vivo swine model. Methods A …

We have previously shown that transplantation of autologously derived, respiration-competent
mitochondria by direct injection into the heart following transient ischemia and reperfusion …

Previously, we have demonstrated that the transplantation of viable, structurally intact,
respiration competent mitochondria into the ischemic myocardium during early reperfusion …

Mitochondrial transplantation is a novel therapeutic intervention to treat ischemia/reperfusion
related disorders. The method for mitochondrial transplantation is simple and rapid and …

Necrosis and apoptosis differentially contribute to myocardial injury. Determination of the
contribution of these processes in ischemia-reperfusion injury would allow for the preservation …