The human SLC29 family of proteins contains four members, designated equilibrative nucleoside
transporters (ENTs) because of the properties of the first-characterised family member, …

Gemcitabine (2′,2′-difluorodeoxycytidine) is a novel pyrimidine nucleoside drug with
clinical efficacy in several common epithelial cancers. We have proposed that gemcitabine …

Purpose: Gemcitabine monotherapy is the standard palliative chemotherapy for pancreatic
adenocarcinoma. Gemcitabine requires plasma membrane nucleoside transporter proteins to …

In most mammalian Cells nucleoside uptake occurs primarily via broad-specificity, es (e,
equilibrative; s, sensitive to NBMPR inhibition) transporters that are potentlyinhibited by …

The human concentrative (Na + -linked) plasma membrane transport proteins hCNT1 and
hCNT2 are selective for pyrimidine nucleosides (systemcit) and purine nucleosides (system cif)…

The uptake of nucleosides (or nucleobases) is essential for nucleic acid synthesis in many
human cell types and in parasitic organisms that cannot synthesize nucleotides de novo. The …

Nucleoside transport in humans is mediated by members of two unrelated protein families,
the SLC28 family of cation-linked concentrative nucleoside transporters (CNTs) and the …

The first mammalian examples of the equilibrative nucleoside transporter family to be
characterized, hENT1 and hENT2, were passive transporters located predominantly in the plasma …

The clinical efficacy of anticancer nucleoside drugs depends on a complex interplay of
transporters mediating entry of nucleoside drugs into cells, efflux mechanisms that remove drugs …

Hydrophilic purine and pyrimidine nucleosides rely on specialized carrier proteins for their
membrane translocation. The recent identification of two gene families encoding equilibrative …