The quantification of big pools of diverse molecules provides important insights on brain
function, but is often restricted to a limited number of observations, which impairs integration …

Background Previous studies suggest that transcranial magnetic stimulation exerts
antidepressant effects by altering functional connectivity (FC). However, knowledge about this …

Animal studies using selective serotonin reuptake inhibitors (SSRIs) and learning paradigms
have demonstrated that serotonin is important for flexibility in executive functions and …

The accurate segmentation of in vivo magnetic resonance imaging (MRI) data is a crucial
prerequisite for the reliable assessment of disease progression, patient stratification or the …

Impaired cognitive flexibility represents a widespread symptom in psychiatric disorders,
including major depressive disorder (MDD), a disease, characterized by an imbalance of …

Background Electroconvulsive therapy (ECT) constitutes one of the most effective
antidepressant treatment strategies in major depression (MDD). Despite its common use and …

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation technique
that modulates brain activity by producing an electric field in the targeted brain region [1]…

Background Comprehensive description of ketamine’s molecular binding profile becomes
increasingly pressing as use in real-life patient cohorts widens. Animal studies attribute a …

An essential core function of one's cognitive flexibility is the use of acquired knowledge and
skills to adapt to ongoing environmental changes. Animal models have highlighted the …

The N-methyl-d-aspartate receptor (NMDAR) plays a crucial role in neurodegenerative
diseases such as Alzheimer disease and in the treatment of major depression by fast-acting …