Aprotic solvents are usually preferred for the S N 2 reactions, because nucleophilicity and
hence S N 2 reactivity are severely retarded by the influence of the partial positive charge of …

Designing highly conductive and (electro)chemical stable inorganic solid electrolytes using
cost-effective materials is crucial for developing all-solid-state batteries. Here, we report …

New therapeutic strategies are needed to combat the tuberculosis pandemic and the spread
of multidrug-resistant (MDR) and extensively drug-resistant (XDR) forms of the disease, …

Parkinson disease (PD), progressive supranuclear palsy (PSP), and multiple-system
atrophy (MSA) are known to affect dopaminergic neurons of the brain stem and striatum with …

Objective Cerebral microbleeds (CMBs) are a neuroimaging marker of small vessel disease
(SVD) with relevance for understanding disease mechanisms in cerebrovascular disease, …

Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis,
exemplifies the classically held view of stepwise cancer development 1 . The current model of …

Abstract The aim of this study was to evaluate the feasibility of using [ 18 F] 3′-deoxy-3′-fluorothymidine
(FLT) positron emission tomography (PET) for the diagnosis and grading of …

Cerebral blood flow (CBF) is decreased and cognitive dysfunction develops in the advanced
stages of heart failure. However, few data are available regarding the factors associated …

Pancreatic adenocarcinoma presents as a spectrum of a highly aggressive disease in patients.
The basis of this disease heterogeneity has proved difficult to resolve due to poor tumor …

The FDA has published recommendations for sponsors who wish to request a waiver of in
vivo bioavailability (BA) or bioequivalence (BE) studies for immediate release (IR) solid oral …