Crohn's disease 1 , 2 and ulcerative colitis, the two main types of chronic inflammatory
bowel disease, are multifactorial conditions of unknown aetiology. A susceptibility locus for …

Several risk factors for Crohn's disease have been identified in recent genome-wide association
studies. To advance gene discovery further, we combined data from three studies on …

BACKGROUND Crohn's disease is a heterogeneous disorder with both a genetic and
environmental aetiology. Clinical classifications of the disease, such as the newly proposed …

CARD15/NOD2 encodes a protein involved in bacterial recognition by monocytes. Mutations
in CARD15 have recently been found in patients with Crohn disease (CD), a chronic …

To identify novel susceptibility loci for Crohn disease (CD), we undertook a genome-wide
association study with more than 300,000 SNPs characterized in 547 patients and 928 controls…

We used a candidate gene approach to identify a set of SNPs, located in a predicted regulatory
region on chromosome 1q44 downstream of NLRP3 (previously known as CIAS1 and …

Objective. A model based on clinical characteristics at diagnosis and predicting the early
development of disabling Crohn's disease (CD) has recently been proposed in order to target …

Background: Crohn’s disease is a heterogeneous entity. Disease behaviour, characterised
as stricturing, penetrating, or non-stricturing non-penetrating, is a clinically important …

Background: Two-thirds to three-fourths of patients with either refractory luminal or fistulizing
Crohn disease respond to infliximab treatment. The ability or inability to respond seems to …

Resistance to glucocorticoid therapy has been observed in patients with autoimmune/inflammatory
diseases and may be related to the inflammatory process itself. The aim of this study …