User profiles for Jacob G. Dubroff
Jacob DubroffAssociate Professor of Radiology, University of Pennsylvania Verified email at upenn.edu Cited by 1118 |
PennPET explorer: human imaging on a whole-body imager
…, JG Dubroff, G Muehllehner… - Journal of Nuclear …, 2020 - Soc Nuclear Med
The PennPET Explorer, a prototype whole-body imager currently operating with a 64-cm axial
field of view, can image the major body organs simultaneously with higher sensitivity than …
field of view, can image the major body organs simultaneously with higher sensitivity than …
Molecular imaging of pulmonary inflammation in users of electronic and combustible cigarettes: a pilot study
Electronic cigarette (EC) use has increased dramatically, particularly among adolescents and
young adults, and, like cigarette use, can cause pulmonary inflammation and increase the …
young adults, and, like cigarette use, can cause pulmonary inflammation and increase the …
[HTML][HTML] Regional brain amyloid-β accumulation associates with domain-specific cognitive performance in Parkinson disease without dementia
Parkinson disease patients develop clinically significant cognitive impairment at variable
times over their disease course, which is often preceded by milder deficits in memory, visuo-…
times over their disease course, which is often preceded by milder deficits in memory, visuo-…
[HTML][HTML] The role of resting myocardial blood flow and myocardial blood flow reserve as a predictor of major adverse cardiovascular outcomes
…, DA Mankoff, DA Pryma, DJ Rader, JG Dubroff - PLoS …, 2020 - journals.plos.org
Cardiac perfusion PET is increasingly used to assess ischemia and cardiovascular risk and
can also provide quantitative myocardial blood flow (MBF) and flow reserve (MBFR) values. …
can also provide quantitative myocardial blood flow (MBF) and flow reserve (MBFR) values. …
Rates of longitudinal change in 18F‐flortaucipir PET vary by brain region, cognitive impairment, and age in atypical Alzheimer's disease
Introduction Longitudinal positron emission tomography (PET) studies of tau accumulation
in Alzheimer's disease (AD) have noted reduced increases or frank decreases in tau signal. …
in Alzheimer's disease (AD) have noted reduced increases or frank decreases in tau signal. …
Decreased nicotinic receptor availability in smokers with slow rates of nicotine metabolism
The nicotine metabolite ratio (NMR), a stable measure of hepatic nicotine metabolism via
the CYP2A6 pathway and total nicotine clearance, is a predictive biomarker of response to …
the CYP2A6 pathway and total nicotine clearance, is a predictive biomarker of response to …
An open-label efficacy trial of escitalopram for night eating syndrome
…, RI Berkowitz, LA Hesson, RH Moore, JG Dubroff… - Eating behaviors, 2013 - Elsevier
OBJECTIVE: Night eating syndrome (NES) has become increasingly recognized as a
disorder in need of effective treatments. Selective serotonin reuptake inhibitors have shown …
disorder in need of effective treatments. Selective serotonin reuptake inhibitors have shown …
Positron emission tomography of neuroimmune responses in humans: insights and intricacies
The brain's immune system plays a critical role in responding to immune challenges and
maintaining homeostasis. However, dysregulated neuroimmune function contributes to …
maintaining homeostasis. However, dysregulated neuroimmune function contributes to …
[HTML][HTML] Gait abnormalities and non-motor symptoms predict abnormal dopaminergic imaging in presumed drug-induced Parkinsonism
WW Aamodt, JG Dubroff, G Cheng, B Taylor… - npj Parkinson's …, 2022 - nature.com
Drug-induced parkinsonism (DIP) can be clinically indistinguishable from degenerative
parkinsonism, and bedside assessments are needed to differentiate between these conditions. …
parkinsonism, and bedside assessments are needed to differentiate between these conditions. …
Selectivity of probes for PET imaging of dopamine D3 receptors
Dopamine D3 receptors have key roles in behavioral reward, addiction, Parkinson’s disease,
and schizophrenia, and there is interest in studying their role in these disorders using PET. …
and schizophrenia, and there is interest in studying their role in these disorders using PET. …