User profiles for Jacob G. Dubroff

Jacob Dubroff

Associate Professor of Radiology, University of Pennsylvania
Verified email at upenn.edu
Cited by 1118

PennPET explorer: human imaging on a whole-body imager

…, JG Dubroff, G Muehllehner… - Journal of Nuclear …, 2020 - Soc Nuclear Med
The PennPET Explorer, a prototype whole-body imager currently operating with a 64-cm axial
field of view, can image the major body organs simultaneously with higher sensitivity than …

Molecular imaging of pulmonary inflammation in users of electronic and combustible cigarettes: a pilot study

…, RH Mach, HR Kranzler, JG Dubroff - Journal of Nuclear …, 2023 - Soc Nuclear Med
Electronic cigarette (EC) use has increased dramatically, particularly among adolescents and
young adults, and, like cigarette use, can cause pulmonary inflammation and increase the …

[HTML][HTML] Regional brain amyloid-β accumulation associates with domain-specific cognitive performance in Parkinson disease without dementia

…, AS Chen-Plotkin, HI Hurtig, AD Siderowf, JG Dubroff… - PLoS …, 2017 - journals.plos.org
Parkinson disease patients develop clinically significant cognitive impairment at variable
times over their disease course, which is often preceded by milder deficits in memory, visuo-…

[HTML][HTML] The role of resting myocardial blood flow and myocardial blood flow reserve as a predictor of major adverse cardiovascular outcomes

…, DA Mankoff, DA Pryma, DJ Rader, JG Dubroff - PLoS …, 2020 - journals.plos.org
Cardiac perfusion PET is increasingly used to assess ischemia and cardiovascular risk and
can also provide quantitative myocardial blood flow (MBF) and flow reserve (MBFR) values. …

Rates of longitudinal change in 18F‐flortaucipir PET vary by brain region, cognitive impairment, and age in atypical Alzheimer's disease

…, DJ Irwin, JC Gee, JG Dubroff… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction Longitudinal positron emission tomography (PET) studies of tau accumulation
in Alzheimer's disease (AD) have noted reduced increases or frank decreases in tau signal. …

Decreased nicotinic receptor availability in smokers with slow rates of nicotine metabolism

JG Dubroff, RK Doot, M Falcone… - Journal of Nuclear …, 2015 - Soc Nuclear Med
The nicotine metabolite ratio (NMR), a stable measure of hepatic nicotine metabolism via
the CYP2A6 pathway and total nicotine clearance, is a predictive biomarker of response to …

An open-label efficacy trial of escitalopram for night eating syndrome

…, RI Berkowitz, LA Hesson, RH Moore, JG Dubroff… - Eating behaviors, 2013 - Elsevier
OBJECTIVE: Night eating syndrome (NES) has become increasingly recognized as a
disorder in need of effective treatments. Selective serotonin reuptake inhibitors have shown …

Positron emission tomography of neuroimmune responses in humans: insights and intricacies

NR Raval, RR Wetherill, CE Wiers, JG Dubroff… - Seminars in nuclear …, 2023 - Elsevier
The brain's immune system plays a critical role in responding to immune challenges and
maintaining homeostasis. However, dysregulated neuroimmune function contributes to …

[HTML][HTML] Gait abnormalities and non-motor symptoms predict abnormal dopaminergic imaging in presumed drug-induced Parkinsonism

WW Aamodt, JG Dubroff, G Cheng, B Taylor… - npj Parkinson's …, 2022 - nature.com
Drug-induced parkinsonism (DIP) can be clinically indistinguishable from degenerative
parkinsonism, and bedside assessments are needed to differentiate between these conditions. …

Selectivity of probes for PET imaging of dopamine D3 receptors

RK Doot, JG Dubroff, KJ Labban, RH Mach - Neuroscience letters, 2019 - Elsevier
Dopamine D3 receptors have key roles in behavioral reward, addiction, Parkinson’s disease,
and schizophrenia, and there is interest in studying their role in these disorders using PET. …