User profiles for Jacek Capala

Jacek Capala

Program Director, NIH/NCI
Verified email at mail.nih.gov
Cited by 4847

Boron neutron capture therapy for glioblastoma multiforme: interim results from the phase I/II dose-escalation studies

AD Chanana, J Capala, M Chadha, JA Coderre… - …, 1999 - journals.lww.com
OBJECTIVE: The primary objective of these Phase I/II dose-escalation studies is to evaluate
the safety of boronophenylalanine (BPA)-fructose-mediated boron neutron capture therapy (…
Save Cite Cited by 241 Related articles All 7 versions
[HTML] nih.gov

[HTML][HTML] Prostate specific membrane antigen—a target for imaging and therapy with radionuclides

K Bouchelouche, PL Choyke, J Capala - Discovery medicine, 2010 - ncbi.nlm.nih.gov
Prostate cancer continues to represent a major health problem, and yet there is no effective
treatment available for advanced metastatic disease. Thus, there is an urgent need for the …
Save Cite Cited by 191 Related articles All 10 versions
[PDF] psu.edu

Boron neutron capture therapy for glioblastoma multiforme: clinical studies in Sweden

J Capala, B H.-Stenstam, K Sköld… - Journal of neuro …, 2003 - Springer
A boron neutron capture therapy (BNCT) facility has been constructed at Studsvik, Sweden.
It includes two filter/moderator configurations. One of the resulting neutron beams has been …
Save Cite Cited by 201 Related articles All 23 versions
[HTML] nih.gov

Affibody Molecules for In vivo Characterization of HER2-Positive Tumors by Near-Infrared Imaging

…, G Kramer-Marek, A Gandjbakhche, J Capala - Clinical Cancer …, 2008 - AACR
Purpose: HER2 overexpression has been associated with a poor prognosis and resistance
to therapy in breast cancer patients. We are developing molecular probes for in vivo …
Save Cite Cited by 191 Related articles All 8 versions
[PDF] researchgate.net

Boron neutron capture therapy for glioblastoma multiforme using p-boronophenylalanine and epithermal neutrons: Trial design and early clinical results

…, EH Elowitz, M Chadha, R Bergland, J Capala… - Journal of neuro …, 1997 - Springer
A Phase I/II clinical trial of boron neutroncapture therapy (BNCT) for glioblastoma multiforme
is underwayusing the amino acid analog p-boronophenylalanine (BPA) andthe epithermal …
Save Cite Cited by 215 Related articles All 12 versions
[HTML] nih.gov

[HTML][HTML] Normal tissue protection for improving radiotherapy: Where are the Gaps?

…, HB Stone, RS Wong, J Capala… - Translational cancer …, 2012 - ncbi.nlm.nih.gov
Any tumor could be controlled by radiation therapy if sufficient dose were delivered to all
tumor cells. Although technological advances in physical treatment delivery have been …
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Boronated epidermal growth factor as a potential targeting agent for boron neutron capture therapy of brain tumors

J Capala, RF Barth, M Bendayan, M Lauzon… - Bioconjugate …, 1996 - ACS Publications
In order for boron neutron capture therapy (BNCT) to be successful, a large number (∼10 9
) of 10 B atoms must be delivered to each cancer cell in order to sustain a lethal 10 B(n, α) 7 …
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[HTML] springer.com

[HTML][HTML] [18F]FBEM-ZHER2:342-Affibody molecule—a new molecular tracer for in vivo monitoring of HER2 expression by positron emission tomography

…, L Martiniova, E Jagoda, SB Lee, J Capala - European journal of …, 2008 - Springer
[18F]FBEM-ZHER2:342-Affibody molecule—a new molecular tracer for in vivo monitoring of
HER2 expression by positron emission tomography | European Journal of Nuclear Medicine …
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Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA)

R Henriksson, J Capala, A Michanek… - Radiotherapy and …, 2008 - Elsevier
BACKGROUND AND PURPOSE: To evaluate the efficacy and safety of boron neutron
capture therapy (BNCT) for glioblastoma multiforme (GBM) using a novel protocol for the …
Save Cite Cited by 147 Related articles All 17 versions

Boron neutron-capture therapy (BNCT) for glioblastoma multiforme (GBM) using the epithermal neutron beam at the Brookhaven National Laboratory

M Chadha, J Capala, JA Coderre, EH Elowitz… - International Journal of …, 1998 - Elsevier
Objective: Boron neutron-capture therapy (BNCT) is a binary form of radiation therapy based
on the nuclear reactions that occur when boron ( 10 B) is exposed to thermal neutrons. …
Save Cite Cited by 148 Related articles All 13 versions