Understanding the changes in the brain which occur in the transition from normal to addictive
behavior has major implications in public health. Here we postulate that while reward …

Imaging studies have revealed neurochemical and functional changes in the brains of drug-addicted
subjects that provide new insights into the mechanisms underlying addiction. …

The involvement of dopamine in drug reinforcement is well recognized but its role in drug
addiction is much less clear. Imaging studies have shown that the reinforcing effects of drugs of …

… Joanna S Fowler, PhD Joanna S Fowler … Joanna Fowler was the principal investigator
of the study, responsible for radiochemistry, and wrote the paper. …

THE massive health problem associated with cigarette smoking is exacerbated by the addictive
properties of tobacco smoke and the limited success of current approaches to cessation …

The distribution volume ratio (DVR), which is a linear function of receptor availability, is widely
used as a model parameter in imaging studies. The DVR corresponds to the ratio of the …

A graphical method of analysis applicable to ligands that bind reversibly to receptors or
enzymes requiring the simultaneous measurement of plasma and tissue radioactivities for …

The ability of drugs of abuse to increase dopamine in nucleus accumbens underlies their
reinforcing effects. However, preclinical studies have shown that with repeated drug exposure …

OBJECTIVE: The role of dopamine in the addictive process (loss of control and compulsive
drug intake) is poorly understood. A consistent finding in drug-addicted subjects is a lower …

Cocaine blocks the reuptake of dopamine, a neurotransmitter involved in the control of
movement, cognition, motivation and reward. This leads to an increase in extracellular dopamine; …