Methionine dependency and cancer treatment

…, A Demiden, JC Maurizis, JC Madelmont… - Cancer treatment …, 2003 - Elsevier
Conventional chemotherapies have showed their limits, notably for patients with advanced
cancer. New therapeutic strategies must be identified, and the metabolic abnormalities of …

Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion

E Debiton, JC Madelmont, J Legault… - Cancer chemotherapy …, 2003 - Springer
Purpose The quaternary benzophenanthridine alkaloid sanguinarine exhibits a broad range
of activity, including cytotoxicity against various human tumour and normal cell lines. Here, …

[PDF][PDF] Phase II scintigraphic clinical trial of malignant melanoma and metastases with iodine-123-N-(2-diethylaminoethyl 4-iodobenzamide)

…, JF Bonafous, FJ Bacin, JC Madelmont… - Journal of Nuclear …, 1993 - Soc Nuclear Med
RESULTS After injection of â€@ I-BZA, no short-term or long term side effects were observed.
The investigators ob served normal quickly distributed radioactivity in blood circulation. …

Isotopic effect study of propofol deuteration on the metabolism, activity, and toxicity of the anesthetic

…, J Legailliard, MJ Galmier, JC Madelmont - Journal of medicinal …, 2002 - ACS Publications
The use of isotopic substitution to delay the oxidative metabolism of the anesthetic propofol
1 was studied. The aromatic hydrogens of propofol 1 were replaced by deuterium to produce …

Evaluation of Radiolabeled (Hetero)Aromatic Analogues of N-(2-diethylaminoethyl)-4-iodobenzamide for Imaging and Targeted Radionuclide Therapy of Melanoma

…, J Maublant, JC Teulade, JC Madelmont… - Journal of medicinal …, 2008 - ACS Publications
Targeted radionuclide therapy using radioiodinated compounds with a specific affinity for
melanoma tissue is a promising treatment for disseminated melanoma, but the candidate with …

[PDF][PDF] Synthesis and evaluation of new iodine-125 radiopharmaceuticals as potential tracers for malignant melanoma

…, MFC Moreau, PG Labarre, JC Madelmont… - Journal of Nuclear …, 1991 - Soc Nuclear Med
The synthesis, labeling, and biodistribution of four 1251 radiopharmaceuticals designed to
localize in melanoma were tested. Uptake in tumors was demonstrated by autoradiography of …

Phase II trial of the association of a methionine-free diet with cystemustine therapy in melanoma and glioma

…, E Cellarier, JC Madelmont… - Anticancer …, 2009 - ar.iiarjournals.org
Background: In a previous phase I clinical trial of dietary methionine (MET) restriction with
cystemustine treatment for melanoma or glioma, we determined the optimal MET-free diet …

In vivo and in situ modulation of the expression of genes involved in metastasis and angiogenesis in a patient treated with topical imiquimod for melanoma skin …

…, P Déchelotte, JC Madelmont… - British Journal of …, 2004 - academic.oup.com
There is a growing body of evidence to support the efficacy of topical imiquimod in the
treatment of primary skin carcinomas. Conflicting data exist concerning the use of imiquimod for …

Synthesis and cytotoxic properties of new fluorodeoxyglucose-coupled chlorambucil derivatives

…, M Borel, M Madesclaire, JC Madelmont… - Bioorganic & medicinal …, 2008 - Elsevier
Frequently used in the treatment of malignant cells, alkylating agents, like most anticancer
substances, produce adverse side effects caused by the toxicity of the agents toward normal …

Proteomic studies of B16 lines: involvement of annexin A1 in melanoma dissemination

…, N Moins, J Maublant, JC Madelmont… - … et Biophysica Acta (BBA …, 2009 - Elsevier
To identify proteins involved in melanoma metastasis mechanisms, comparative proteomic
studies were undertaken on B16F10 and B16Bl6 melanoma cell lines and their subsequent …