Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality
…, H Amols, Z Fuks, S Leibel, JA Koutcher - International Journal of …, 2000 - Elsevier
Purpose: The goals of this study were to survey and summarize the advances in imaging that
have potential applications in radiation oncology, and to explore the concept of integrating …
have potential applications in radiation oncology, and to explore the concept of integrating …
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Cellular senescence has been theorized to oppose neoplastic transformation triggered by
activation of oncogenic pathways in vitro 1 , 2 , 3 , but the relevance of senescence in vivo has …
activation of oncogenic pathways in vitro 1 , 2 , 3 , but the relevance of senescence in vivo has …
[PDF][PDF] Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
…, Y Chen, S Chandarlapaty, VK Arora, C Le, J Koutcher… - Cancer cell, 2011 - cell.com
Prostate cancer is characterized by its dependence on androgen receptor (AR) and frequent
activation of PI3K signaling. We find that AR transcriptional output is decreased in human …
activation of PI3K signaling. We find that AR transcriptional output is decreased in human …
[HTML][HTML] Pten dose dictates cancer progression in the prostate
LC Trotman, M Niki, ZA Dotan, JA Koutcher… - PLoS …, 2003 - journals.plos.org
… C57BL6/J blastocysts, then transferred to pseudopregnant foster mothers. Chimeric males
were mated with C57BL6/J females (Jackson Laboratory, Bar Harbor, Maine, United States), …
were mated with C57BL6/J females (Jackson Laboratory, Bar Harbor, Maine, United States), …
[HTML][HTML] Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
… have shown that HKI-272 can overcome T790M-mediated resistance only at suprapharmacologic
concentrations (44), and we have obtained analogous results with BIBW-2992 (J. …
concentrations (44), and we have obtained analogous results with BIBW-2992 (J. …
Correlation of proton MR spectroscopic imaging with gleason score based on step-section pathologic analysis after radical prostatectomy
PURPOSE: To determine whether hydrogen 1 magnetic resonance (MR) spectroscopic imaging
can be used to predict aggressiveness of prostate cancer. MATERIALS AND METHODS…
can be used to predict aggressiveness of prostate cancer. MATERIALS AND METHODS…
Identification of a tumour suppressor network opposing nuclear Akt function
LC Trotman, A Alimonti, PP Scaglioni, JA Koutcher… - Nature, 2006 - nature.com
The proto-oncogene AKT (also known as PKB) is activated in many human cancers, mostly
owing to loss of the PTEN tumour suppressor 1 . In such tumours, AKT becomes enriched at …
owing to loss of the PTEN tumour suppressor 1 . In such tumours, AKT becomes enriched at …
Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography
…, F Augensen, J Koutcher, J Zweit, J Humm… - Cancer research, 1998 - AACR
We report a series of studies that assess the feasibility and sensitivity of imaging of herpes
virus type one thymidine kinase (HSV1-tk) gene transfer and expression with [ 124 I]-5-iodo-2…
virus type one thymidine kinase (HSV1-tk) gene transfer and expression with [ 124 I]-5-iodo-2…
[HTML][HTML] Applications of magnetic resonance in model systems: cancer therapeutics
JL Evelhoch, RJ Gillies, GS Karczmar, JA Koutcher… - Neoplasia, 2000 - Elsevier
The lack of information regarding the metabolism and pathophysiology of individual tumors
limits, in part, both the development of new anti-cancer therapies and the optimal …
limits, in part, both the development of new anti-cancer therapies and the optimal …
ATP depletion+ pyrimidine depletion can markedly enhance cancer therapy: fresh insight for a new approach
DS Martin, JR Bertino, JA Koutcher - Cancer research, 2000 - AACR
In the 1980s, necrosis was considered the mode of cell death induced by DNA-damaging
anticancer agents because of the activity of PARP. 3 PARP is activated by the DNA strand …
anticancer agents because of the activity of PARP. 3 PARP is activated by the DNA strand …