Transthyretin amyloidosis is a progressive and eventually fatal disease primarily
characterized by sensory, motor, and autonomic neuropathy and/or cardiomyopathy. Given its …

The systemic amyloidoses are a family of diseases induced by misfolded or misassembled
proteins. Extracellular deposition of these proteins as soluble or insoluble cross-sheets …

Transthyretin amyloidosis is a fatal disorder that is characterized primarily by progressive
neuropathy and cardiomyopathy. It occurs in both a mutant form (with autosomal dominant …

… j ( t ) , t > j } j = 0 ∞ are independent of each other and of all other random variables in the
model. We start the process χ j ( t ) by setting χ j ( j ) = 1 if the project that arrives at date j … β j is, …

Background Patisiran, an investigational RNA interference therapeutic agent, specifically
inhibits hepatic synthesis of transthyretin. Methods In this phase 3 trial, we randomly assigned …

We derive a parsimonious rational model of active portfolio management that reproduces
many regularities widely regarded as anomalous. Fund flows rationally respond to past …

Background— Cardiac transthyretin (ATTR) amyloidosis is a progressive and fatal
cardiomyopathy for which several promising therapies are in development. The diagnosis is …

A dynamic model of a multistage investment project that captures many features of research
and development (R&D) ventures and start-up companies is developed. An important …

Background Hereditary transthyretin amyloidosis is caused by pathogenic single-nucleotide
variants in the gene encoding transthyretin (TTR) that induce transthyretin misfolding and …

Background Transthyretin amyloidosis, also called ATTR amyloidosis, is associated with
accumulation of ATTR amyloid deposits in the heart and commonly manifests as progressive …