Changes in plasma nitrite concentration in the human forearm circulation have recently
been shown to reflect acute changes in endothelial nitric oxide synthase (eNOS)-activity. …

The nitrite anion is reduced to nitric oxide (NO • ) as oxygen tension decreases. Whereas
this pathway modulates hypoxic NO • signaling and mitochondrial respiration and limits …

The present study explored the role of myoglobin (Mb) in cardiac NO homeostasis and its
functional relevance by employing isolated hearts of wild-type (WT) and myoglobin knockout …

Background— In this study, we developed and validated a new approach for in vivo visualization
of inflammatory processes by magnetic resonance imaging using biochemically inert …

Brown adipose tissue (BAT) is specialized in energy expenditure, making it a potential target
for anti-obesity therapies 1 , 2 , 3 , 4 , 5 . Following exposure to cold, BAT is activated by the …

For the specific analysis of endothelial NO synthase (eNOS) function in the coronary vasculature,
we generated a mouse homozygous for a defective eNOS gene (eNOS−/−). Western …

Although the primary function of myoglobin (Mb) has been considered to be cellular oxygen
storage and supply, recent studies have suggested to classify Mb as a multifunctional …

Background— HMG-CoA reductase inhibitors, such as simvastatin, have been shown to
exhibit pronounced immunomodulatory effects independent of lipid lowering but to date have …

Background— HMG-CoA-reductase inhibitors have been shown to exhibit pronounced
immunomodulatory effects independent of lipid lowering. We have recently demonstrated that …

To elucidate the physiological role of the AMP-adenosine metabolic cycle and to investigate
the relation between AMP and adenosine formation, the O 2 supply of isolated guinea pig …