Purpose: To provide proof of principle of safety, breast tumor–specific uptake, and positive
tumor margin assessment of the systemically administered near-infrared fluorescent tracer …

Multispectral optoacoustic (photoacoustic) tomography (MSOT) is a hybrid modality that can
image through several millimeters to centimeters of diffuse tissues, attaining resolutions …

Small and flat adenomas are known to carry a high miss-rate during standard white-light
endoscopy. Increased detection rate may be achieved by molecular fluorescence endoscopy …

The visual identification and demarcation of tumors and tumor margins remains challenging
due to the low optical contrast of cancer cells over surrounding tissues. Fluorescence …

In vivo tumor labeling with fluorescent agents may assist endoscopic and surgical guidance
for cancer therapy as well as create opportunities to directly observe cancer biology in …

White-light surveillance colonoscopy is the standard of care for the detection and removal of
premalignant lesions to prevent colorectal cancer, and the main screening recommendation …

Molecular fluorescence imaging is a commonly used method in various biomedical fields
and is undergoing rapid translation toward clinical applications. Color images are commonly …

Among several techniques considered for surgical and endoscopic imaging, novel optical
methods are evolving as a promising approach for interventional guidance. Pilot clinical …

Background The recent clinical propagation of targeted fluorescence agents brings a
promising alternative in endoscopy by complementing visual disease detection with molecular …

Introduction Successful breast conserving cancer surgeries come along with tumor free
resection margins and account for cosmetic outcome. Positive margins increase the likelihood of …