Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer’s
disease (AD) pathogenesis. The overall load and spatial distribution of brain Aβ can be …

Background and Objectives β-amyloid (Aβ) staging models assume a single spatial-temporal
progression of amyloid accumulation. We assessed evidence for Aβ accumulation …

Objective To develop and evaluate a model for staging cortical amyloid deposition using
PET with high generalizability. Methods Three thousand twenty-seven individuals (1,763 …

Importance Amyloid positron emission tomography (PET) allows the direct assessment of
amyloid deposition, one of the main hallmarks of Alzheimer disease. However, this technique …

Background A long dynamic scanning protocol may be required to accurately measure
longitudinal changes in amyloid load. However, such a protocol results in a lower patient comfort …

Purpose To investigate the sensitivity of visual read (VR) to detect early amyloid pathology
and the overall utility of regional VR. Methods [ 18 F]Flutemetamol PET images of 497 …

Our objective was to determine the optimal approach for assessing amyloid disease in a
cognitively normal elderly population. Methods: Dynamic 18 F-flutemetamol PET scans were …

Although clinical routine focuses on dichotomous and visual interpretation of amyloid PET,
regional image assessment in research settings may yield additional opportunities. …

… prognostic and natural history study - Lopes Alves - 2020 - Alzheimer's & Dementia - Wiley
Online Library … Isadora Lopes Alves and Lyduine Collij contributed equally to this study. …

Introduction Reimbursement of amyloid–positron emission tomography (PET) is lagging due
to the lack of definitive evidence on its clinical utility and cost‐effectiveness. The Amyloid …