User profiles for Iris Zhou
 | Iris Yuwen ZhouMartinos Center for Biomedical Imaging, MGH and Harvard Medical School Verified email at mgh.harvard.edu Cited by 1856 |
[HTML][HTML] Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis
How phosphate levels are detected in mammals is unknown. The bone-derived hormone
fibroblast growth factor 23 (FGF23) lowers blood phosphate levels by reducing kidney …
fibroblast growth factor 23 (FGF23) lowers blood phosphate levels by reducing kidney …
Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via T1-weighted MRI
SNIO–CBP, a single-nanometer iron oxide (SNIO) nanoparticle functionalized with a type I
collagen-binding peptide (CBP), was developed as a T 1 -weighted MRI contrast agent with …
collagen-binding peptide (CBP), was developed as a T 1 -weighted MRI contrast agent with …
[HTML][HTML] Quantitative chemical exchange saturation transfer (CEST) MRI of glioma using Image Downsampling Expedited Adaptive Least-squares (IDEAL) fitting
IY Zhou, E Wang, JS Cheung, X Zhang, G Fulci… - Scientific reports, 2017 - nature.com
Chemical Exchange Saturation Transfer (CEST) MRI is sensitive to dilute metabolites with
exchangeable protons, allowing tissue characterization in diseases such as acute stroke and …
exchangeable protons, allowing tissue characterization in diseases such as acute stroke and …
pH-sensitive MRI demarcates graded tissue acidification during acute stroke―pH specificity enhancement with magnetization transfer and relaxation-normalized …
pH-sensitive amide proton transfer (APT) MRI provides a surrogate metabolic biomarker that
complements the widely-used perfusion and diffusion imaging. However, the endogenous …
complements the widely-used perfusion and diffusion imaging. However, the endogenous …
A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol
Purpose To extend the pH detection range of iopamidol‐based ratiometric chemical exchange
saturation transfer (CEST) MRI at sub‐high magnetic field and establish quantitative renal …
saturation transfer (CEST) MRI at sub‐high magnetic field and establish quantitative renal …
Molecular MRI quantification of extracellular aldehyde pairs for early detection of liver fibrogenesis and response to treatment
Liver fibrosis plays a critical role in the evolution of most chronic liver diseases and is
characterized by a buildup of extracellular matrix, which can progress to cirrhosis, hepatocellular …
characterized by a buildup of extracellular matrix, which can progress to cirrhosis, hepatocellular …
Dual hydrazine-equipped turn-on manganese-based probes for magnetic resonance imaging of liver fibrogenesis
Liver fibrogenesis is accompanied by upregulation of lysyl oxidase enzymes, which catalyze
oxidation of lysine ε-amino groups on the extracellular matrix proteins to form the aldehyde …
oxidation of lysine ε-amino groups on the extracellular matrix proteins to form the aldehyde …
Quantitative chemical exchange saturation transfer (qCEST) MRI–omega plot analysis of RF‐spillover‐corrected inverse CEST ratio asymmetry for simultaneous …
Chemical exchange saturation transfer (CEST) MRI is sensitive to labile proton
concentration and exchange rate, thus allowing measurement of dilute CEST agent and …
concentration and exchange rate, thus allowing measurement of dilute CEST agent and …
Determination of multipool contributions to endogenous amide proton transfer effects in global ischemia with high spectral resolution in vivo chemical exchange …
Purpose Chemical exchange saturation transfer (CEST) MRI has been used for quantitative
assessment of dilute metabolites and/or pH in disorders such as acute stroke and tumor. …
assessment of dilute metabolites and/or pH in disorders such as acute stroke and tumor. …
In vivo pH mapping with omega plot‐based quantitative chemical exchange saturation transfer MRI
Purpose Chemical exchange saturation transfer (CEST) MRI is promising for detecting dilute
metabolites and microenvironment properties, which has been increasingly adopted in …
metabolites and microenvironment properties, which has been increasingly adopted in …