Purpose: Glioblastoma (GBM) is the most common form of malignant glioma in adults.
Although protected by both the blood–brain and blood–tumor barriers, GBMs are actively …

Purpose: Glioblastoma multiforme (GBM) is an aggressive adult brain tumor with a poor
prognosis. One hallmark of GBM is the accumulation of immunosuppressive and tumor-…

As a key component of the standard of care for glioblastoma, radiotherapy induces several
immune resistance mechanisms, such as upregulation of CD47 and PD-L1. Here, leveraging …

Monoclonal antibodies can specifically bind or even inhibit drug targets and have hence
become the fastest growing class of human therapeutics. Although they can be screened for …

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and is virtually
incurable with conventional therapies. Immunotherapy with T cells expressing GBM-specific …

Background Malignant glioma is the most common and lethal primary brain tumour, with
dismal survival rates and no effective treatment. We examined the safety and activity of NSC-…

The promise of gene therapy for health care will not be realized until gene delivery systems
are capable of achieving efficient, cell-specific gene delivery in vivo. Here we describe an …

Adenoviral (Ad) vectors are promising gene therapy vehicles due to their in vivo stability
and efficiency, but their potential utility is compromised by their restricted tropism. Targeting …

Magnetic particles that can be precisely controlled under a magnetic field and transduce
energy from the applied field open the way for innovative cancer treatment. Although these …

The potential utility of oncolytic adenoviruses as anticancer agents is significantly hampered
by the inability of the currently available viral vectors to effectively target micrometastatic …