Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers and
shows resistance to any therapeutic strategy used. Here we tested small-molecule inhibitors …

Here, we show CRISPR/Cas9-based targeted somatic multiplex-mutagenesis and its application
for high-throughput analysis of gene function in mice. Using hepatic single guide RNA (…

Mouse transgenesis has provided fundamental insights into pancreatic cancer, but is limited
by the long duration of allele/model generation. Here we show transfection-based …

BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease without
effective chemopreventive or therapeutic approaches. Although the role of oncogenic Kras …

Purpose: Tumor heterogeneity is a hallmark of pancreatic ductal adenocarcinoma (PDAC).
It determines tumor biology including tumor cellularity (ie, amount of neoplastic cells and …

One of the major challenges in using pancreatic cancer patient–derived organoids (PDOs) in
precision oncology is the time from biopsy to functional characterization. This is particularly …

Evasion of programmed cell death represents a critical form of oncogene addiction in cancer
cells. Understanding the molecular mechanisms underpinning cancer cell survival despite …

Purpose To develop a high spatiotemporal resolution 3D dynamic pulse sequence for
preclinical imaging of hyperpolarized [1‐ 13 C]pyruvate‐to‐[1‐ 13 C]lactate metabolism at 7T. …

Background Metabolic syndrome (MetS) is associated with increased risk of cardiovascular
disease (CVD). One important feature underlying the pathophysiology of many types of CVD …

The in vivo assessment of tissue metabolism represents a novel strategy for the evaluation
of oncologic disease. Hepatocellular carcinoma (HCC) is a high-prevalence, high-mortality …