Incidence of melanoma has been constantly growing during the last decades. Although
most of the new diagnoses are represented by thin melanomas, the number of melanoma-…

Highlights • Exosomes play a key part in tumorigenesis and progression of cancer. • Exosomes
can be isolated from cell culture media and almost all body fluids. • Exosomes are cargos …

The nature of the first Pop III stars is still a mystery and the energy distribution of the first
supernovae is completely unexplored. For the first time we account simultaneously for the …

The incidence of melanoma, among the most lethal cancers, is widespread and increasing.
Metastatic melanoma has a poor prognosis, representing about 90% of skin cancer mortality. …

Immune checkpoint blockade represents a major breakthrough in advanced non-small cell
lung cancer (NSCLC) therapy. However, success is limited to a subset of patients and there is …

Circulating tumor cells (CTCs) are cells spread from the primary tumor into the bloodstream
that might represent an important biomarker in lung cancer. The prognosis of patients …

The origin of Carbon Enhanced Metal-Poor (CEMP-no) stars with low abundances of
neutron-capture elements is still unclear. These stars are ubiquitous, found primarily in the Milky …

Highlights • The blockade of PD-1/PD-L1 and CTLA-4 has shown benefit in NSCLC. •
Clinical studies involving immune checkpoint inhibitors are ongoing in NSCLC. • Checkpoint …

Melanoma is one of the most aggressive tumors of the skin, and its incidence is growing
worldwide. Historically considered a drug resistant disease, since 2011 the therapeutic …

The metal-poor stars in the Galactic halo are thought to show the imprints of the first (Pop III)
stars, and thus provide a glance at the first episodes of star formation. In this work, we aim at …