A new naphthalene derivative with anti-amyloidogenic activity as potential therapeutic agent for Alzheimer's disease
…, R Dapueto, MD Santi, I Kreimerman… - Bioorganic & Medicinal …, 2020 - Elsevier
The aggregation of β-amyloid peptides is associated to neurodegeneration in Alzheimer’s
disease (AD) patients. Consequently, the inhibition of both oligomerization and fibrillation of β-…
disease (AD) patients. Consequently, the inhibition of both oligomerization and fibrillation of β-…
[18F] Amylovis as a Potential PET Probe for β-Amyloid Plaque: Synthesis, In Silico, In vitro and In vivo Evaluations
…, F Zoppolo, I Kreimerman… - Current …, 2019 - ingentaconnect.com
Background: Alzheimer’s disease (AD) is the most common form of dementia. Neuroimaging
methods have widened the horizons for AD diagnosis and therapy. The goals of this work …
methods have widened the horizons for AD diagnosis and therapy. The goals of this work …
Automated radiosynthesis of [11C] L-deprenyl-D2 and [11C] D-deprenyl using a commercial platform
P Buccino, I Kreimerman, K Zirbesegger… - Applied Radiation and …, 2016 - Elsevier
Two 11 C-labelled PET tracers, (R)-N-[ 11 C]methyl-N-(3,3-dideuteropropargyl)-1-phenylpropan-2-amine
([ 11 C]L-deprenyl-D 2, [ 11 C]DED) and (S)-N-[ 11 C]methyl-N-propargyl-1-…
([ 11 C]L-deprenyl-D 2, [ 11 C]DED) and (S)-N-[ 11 C]methyl-N-propargyl-1-…
[HTML][HTML] Biological Assessment of a 18F-Labeled Sulforhodamine 101 in a Mouse Model of Alzheimer's Disease as a Potential Astrocytosis Marker
I Kreimerman, AL Reyes, A Paolino, T Pardo… - Frontiers in …, 2019 - frontiersin.org
Neurodegenerative diseases have mainly been associated with neuronal death. Recent
investigations have shown that astroglia may modulate neuroinflammation in the early and late …
investigations have shown that astroglia may modulate neuroinflammation in the early and late …
Synthesis of [18F] 2B-SRF101: a sulfonamide derivative of the fluorescent dye Sulforhodamine 101
I Kreimerman, W Porcal, S Olivera… - Current …, 2017 - ingentaconnect.com
Background: The red fluorescent dye Sulforhodamine 101 (SR101) has been used in
neuroscience research as a useful tool for staining of astrocytes, since it has been reported as a …
neuroscience research as a useful tool for staining of astrocytes, since it has been reported as a …
Dosimetry and toxicity studies of the novel sulfonamide derivative of Sulforhodamine 101 ([18F] SRF101) at a preclinical level
I Kreimerman, E Mora-Ramirez, L Reyes… - Current …, 2019 - ingentaconnect.com
Background: The SR101 N-(3-[18F]Fluoropropyl) sulfonamide ([18F]SRF101) is a
Sulforhodamine 101 derivative that was previously synthesised by our group. The fluorescent dye …
Sulforhodamine 101 derivative that was previously synthesised by our group. The fluorescent dye …
Comparative In Vitro Study of 11C-Methionine and 11C-Deuterodeprenyl Uptake in Three Human Glioma Cell Lines
E Vasilskis, I Kreimerman, S Olivera… - Cancer Biotherapy …, 2017 - liebertpub.com
Aim: To compare the uptake of 11 C-deuterodeprenyl ( 11 C-DED) and 11 C-methionine ( 11
C-MET) in three human glioma cell lines and study the relationship with glial fibrillary acid …
C-MET) in three human glioma cell lines and study the relationship with glial fibrillary acid …
[HTML][HTML] An efficient preparation of labelling precursor of [11C]L-deprenyl-D2 and automated radiosynthesis
K Zirbesegger, P Buccino, I Kreimerman… - EJNMMI …, 2017 - Springer
Background The synthesis of [ 11 C]L-deprenyl-D 2 for imaging of astrocytosis with positron
emission tomography (PET) in neurodegenerative diseases has been previously reported. [ …
emission tomography (PET) in neurodegenerative diseases has been previously reported. [ …
18F-Sulforhodamine 101 derivative as a potential agent for astrocytosis diagnosis: Labelling and preliminary biological studies
I Kreimerman, AL Reyes, P Buccino, W Porcal, P Oliver… - 2016 - Soc Nuclear Med
2701a Objectives Alzheimers disease (AD) is the most common form of dementia in the aging
population. It is a complex disease that affects many functions and is characterized by a …
population. It is a complex disease that affects many functions and is characterized by a …
Cellular specificity assessment and longitudinal PET study in a transgenic mice model of a 18F-labelled Sulforhodamine 101 in astrocytosis processes in Alzheimer´ s …
I Kreimerman, K Zirbesegger, R Dapueto, F Arredondo… - 2022 - Soc Nuclear Med
2969 Introduction: Alzheimer9s disease (AD) is a neurodegenerative disorder of the Central
Nervous System (CNS), characterized neuropathologically by the presence of amyloid …
Nervous System (CNS), characterized neuropathologically by the presence of amyloid …