Nitro-substituted 1,3-benzothiazinones (nitro-BTZs) are mechanism-based covalent
inhibitors of Mycobacterium tuberculosis decaprenylphosphoryl-β-D-ribose-2′-oxidase (DprE1) …

Background Cancer cachexia represents a central obstacle in medical oncology as it is
associated with poor therapy response and reduced overall survival. Systemic inflammation is …

8‐Nitrobenzothiazinones (BTZs) are a promising class of antimycobacterial agents currently
under investigation in clinical trials. Starting from thiourea derivatives, a new synthetic …

The hypoxia-inducible transcription factor HIF-1 is appreciated as a promising target for
cancer therapy. However, conditional deletion of HIF-1 and HIF-1 target genes in cells of the …

The objective of this study was to compare 18 F-PSMA-1007 PET/CT and 18 F-fluorocholine
PET/CT for the localization of prostate cancer (PCa) biochemical recurrence. Methods: This …

Rationale and Objectives The aim of the present study was to characterize the kinetics of two
nanoparticle-based contrast agents for preclinical imaging, Exitron nano 6000 and Exitron …

1,3-Benzothiazin-4-ones (BTZs) are a promising new class of anti-tuberculosis drug
candidates, some of which have reached clinical trials. The title compound, the benzamide …

The hypoxia-inducible transcription factor HIF-1 is appreciated as a promising target for
cancer therapy. However, conditional deletion of HIF-1 and HIF-1 target genes in cells of the …

In the United States during the 1960s it was recognized that language minority children were
in need of some form of special educational assistance if they were to have the oppor tunity …

The Front Cover shows a synthetic step and example molecule of one of the most toxic
compounds against the single most lethal bacterial pathogen, Mycobacterium tuberculosis, …