User profiles for Igor G. Panyutin

Igor Panyutin

National Institutes of Health, USA
Verified email at helix.nih.gov
Cited by 4246

Quantitative Detection of 125IdU-Induced DNA Double-Strand Breaks with γ-H2AX Antibody

…, EP Rogakou, IG Panyutin… - Radiation …, 2002 - meridian.allenpress.com
Sedelnikova, OA, Rogakou, EP, Panyutin, IG and Bonner, WM Quantitative Detection of 125
IdU-Induced DNA Double-Strand Breaks with γ-H2AX Antibody. Radiat. Res. 158, 486–492 (…

The kinetics of spontaneous DNA branch migration.

IG Panyutin, P Hsieh - … of the National Academy of Sciences, 1994 - National Acad Sciences
An important step in genetic recombination is DNA branch migration, the movement of the
Holliday junction or exchange point between two homologous duplex DNAs. We have …

Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts

MV Sokolov, LB Smilenov, EJ Hall, IG Panyutin… - Oncogene, 2005 - nature.com
That irradiated cells affect their unirradiated ‘bystander’neighbors is evidenced by reports of
increased clonogenic mortality, genomic instability, and expression of DNA-repair genes in …

[HTML][HTML] Expression of pluripotency-associated genes in the surviving fraction of cultured human embryonic stem cells is not significantly affected by ionizing radiation

MV Sokolov, IV Panyutin, MI Onyshchenko, IG Panyutin… - Gene, 2010 - Elsevier
Human embryonic stem cells (hESC) are capable to give rise to all cell types in the human
body during the normal course of development. Therefore, these cells hold a great promise in …

Formation of a single base mismatch impedes spontaneous DNA branch migration

IG Panyutin, P Hsieh - Journal of molecular biology, 1993 - Elsevier
DNA branch migration, a process whereby two homologous DNA duplexes exchange
strands, is an essential component of genetic recombination. Models for homologous …

Intramolecular quadruplex conformation of human telomeric DNA assessed with 125I-radioprobing

Y He, RD Neumann, IG Panyutin - Nucleic acids research, 2004 - academic.oup.com
A repeated non-coding DNA sequence d(TTAGGG) n is present in the telomeric ends of all
human chromosomes. These repeats can adopt multiple inter and intramolecular non-B-DNA …

Phosphorylation of histone H2AX in radiation-induced micronuclei

NG Medvedeva, IV Panyutin, IG Panyutin… - Radiation …, 2007 - meridian.allenpress.com
… 1 Address for correspondence: Department of Nuclear Medicine, Warren G. Magnuson
Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bldg. 10, Room 1C492, …

Stabilization of G-quadruplex in the BCL2 promoter region in double-stranded DNA by invading short PNAs

…, DH Appella, RD Neumann, IG Panyutin - Nucleic acids …, 2009 - academic.oup.com
Numerous regulatory genes have G-rich regions that can potentially form quadruplex structures,
possibly playing a role in transcription regulation. We studied a G-rich sequence in the …

A pivotal role for the structure of the Holliday junction in DNA branch migration.

IG Panyutin, I Biswas, P Hsieh - The EMBO journal, 1995 - embopress.org
Branch migration of a DNA Holliday junction is a key step in genetic recombination that
affects the extent of transfer of genetic information between homologous DNA sequences. We …

Structural polymorphism of intramolecular quadruplex of human telomeric DNA: effect of cations, quadruplex-binding drugs and flanking sequences

…, RD Neumann, IG Panyutin - Nucleic acids …, 2008 - academic.oup.com
G-quadruplex structures formed in the telomeric DNA are thought to play a role in the telomere
function. Drugs that stabilize the G-quadruplexes were shown to have anticancer effects. …