User profiles for Ian Wilson

Ian D Wilson

Imperial College, London
Verified email at imperial.ac.uk
Cited by 49411

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

…, X Zhu, CCD Lee, RTY So, H Lv, CKP Mok, IA Wilson - Science, 2020 - science.org
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome–coronavirus 2 (SARS-CoV-2) has now become a pandemic, but there is currently …

Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution

IA Wilson, JJ Skehel, DC Wiley - Nature, 1981 - nature.com
The haemagglutinin glycoprotein of influenza virus is a trimer comprising two structurally
distinct regions: a triple-stranded coiled-coil of α-helices extends 76 Å from the membrane and …

An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex

…, MR Jackson, PA Peterson, L Teyton, IA Wilson - Science, 1996 - science.org
The central event in the cellular immune response to invading microorganisms is the specific
recognition of foreign peptides bound to major histocompatibility complex (MHC) molecules …

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

…, DM Smith, D Nemazee, JR Teijaro, JE Voss, IA Wilson… - Science, 2020 - science.org
Countermeasures to prevent and treat coronavirus disease 2019 (COVID-19) are a global
health priority. We enrolled a cohort of severe acute respiratory syndrome coronavirus 2 (…

[PDF][PDF] Inhibition and facilitation of nucleic acid amplification

IG Wilson - Applied and environmental microbiology, 1997 - Am Soc Microbiol
Factors that inhibit the amplification of nucleic acids by PCR are present with target DNAs
from many sources. The inhibitors generally act at one or more of three essential points in the …

Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity

J O'brien, I Wilson, T Orton… - European journal of …, 2000 - Wiley Online Library
We show here the identity of Alamar Blue as resazurin. The ‘resazurin reduction test’ has been
used for about 50 years to monitor bacterial and yeast contamination of milk, and also for …

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

…, A Halsall, JN Haselden, AW Nicholls, ID Wilson… - Nature protocols, 2011 - nature.com
Metabolism has an essential role in biological systems. Identification and quantitation of the
compounds in the metabolome is defined as metabolic profiling, and it is applied to define …

Glycosylation and the immune system

PM Rudd, T Elliott, P Cresswell, IA Wilson, RA Dwek - Science, 2001 - science.org
Almost all of the key molecules involved in the innate and adaptive immune response are
glycoproteins. In the cellular immune system, specific glycoforms are involved in the folding, …

Broad neutralization coverage of HIV by multiple highly potent antibodies

…, PG Principal Investigators, WC Koff, IA Wilson… - Nature, 2011 - nature.com
Broadly neutralizing antibodies against highly variable viral pathogens are much sought
after to treat or protect against global circulating viruses. Here we probed the neutralizing …

[HTML][HTML] New world bats harbor diverse influenza A viruses

…, CE Rupprecht, EC Holmes, IA Wilson… - PLoS …, 2013 - journals.plos.org
Aquatic birds harbor diverse influenza A viruses and are a major viral reservoir in nature.
The recent discovery of influenza viruses of a new H17N10 subtype in Central American fruit …