Caribbean ciguatoxins (C-CTXs) are responsible for the widespread occurrence of ciguatera
in the Caribbean Sea. The structure and configuration of C-CTX-1 (1), the major ciguatoxin …

Chemical synthesis was used to prepare the HIV-1 protease specifically 13 C-labelled in
the catalytically essential Asp 25 in each monomer. The NMR chemical shift of the 13 C-…

The structures of haliclonacyclamines A (1) and B (2), and their methiodide salts (3) and (4),
were investigated by 1D- and 2D-NMR experiments, notably DQFCOSY, HMBC, HMQC-…

The malarial parasite Plasmodium falciparum depends on the purine salvage enzyme
hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) to convert purine bases …

Human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) catalyses the synthesis
of the purine nucleoside monophosphates, IMP and GMP, by the addition of a 6-oxopurine …

Proton magnetic resonance imaging (MRI) was used to observe disinfestation heat
treatment-induced injury in the mesocarp of ripening mango cv. Kensington Pride. Injured areas …

Seven cysteine-rich repeats form the ligand-binding region of the low-density lipoprotein (LDL)
receptor. Each of these repeats is assumed to bind a calcium ion, which is needed for …

RJ Lewis, RS Norton, IM Brereton and CD Eccles. Ciguatoxin-2 is a diastereomer of ciguatoxin-3.
Toxicon31, 637–643, 1993.—Ciguatoxin-2, a major ciguatoxin present in the flesh and …

… PvHGPRT binds hypoxanthine with a 2-fold greater affinity compared with guanine (compare
K m values in Table 1) while for PfHGXPRT the K m ratio is 12 (K m is 0.07 ± 0.03 μM for …

Different folivorous marsupials select their food from different subgenera of Eucalyptus, but
the choices cannot be explained by known antifeedants, such as formylated phloroglucinol …