Immuno-PET imaging to assess target engagement: Experience from 89Zr-anti-HER3 mAb (GSK2849330) in patients with solid tumors
…, A McGeoch, M Bergstrom, I McSherry… - Journal of Nuclear …, 2019 - Soc Nuclear Med
PET imaging with radiolabeled drugs provides information on tumor uptake and dose-dependent
target interaction to support selection of an optimal dose for future efficacy testing. In …
target interaction to support selection of an optimal dose for future efficacy testing. In …
A role for heterocellular coupling and EETs in dilation of rat cremaster arteries
IN McSherry, SL Sandow, WB Campbell, JR Falck… - …, 2006 - Taylor & Francis
Objective: The authors probed endothelium-dependent dilation and endothelial cell Ca 2 +
handling in myogenically active resistance arteries. Methods: First-order arteries were …
handling in myogenically active resistance arteries. Methods: First-order arteries were …
Endothelial cell Ca2+ increases are independent of membrane potential in pressurized rat mesenteric arteries
IN McSherry, MM Spitaler, H Takano, KA Dora - Cell calcium, 2005 - Elsevier
In rat mesenteric arteries, the ability of ACh to evoke hyperpolarization of smooth muscle cells
and consummate dilatation relies on an increase in endothelial cell cytosolic free [Ca 2+ ] …
and consummate dilatation relies on an increase in endothelial cell cytosolic free [Ca 2+ ] …
Endothelium-dependent Vasodilation in Myogenically Active Mouse Skeletal Muscle Arterioles: Role of EDH and K+ Channels
SJ Potocnik, I McSherry, H Ding, TV Murphy… - …, 2009 - Taylor & Francis
As smooth muscle cell (SMC) membrane potential (E m ) is critical for vascular responsiveness,
and arteriolar SMCs are depolarized at physiological intraluminal pressures, we …
and arteriolar SMCs are depolarized at physiological intraluminal pressures, we …
Safety, tolerability and pharmacokinetics (PK) of single and repeat nebulised doses of a novel phosphoinositide 3-kinase δ inhibitor (PI3Kδ), GSK2269557 …
R Wilson, A Cahn, A Deans, I McSherry, C Rambaran… - 2013 - Eur Respiratory Soc
Introduction: GSK2269557 was investigated in a single centre, double blind, placebo
controlled trial in healthy male subjects and smokers. Safety, tolerability and PK data were …
controlled trial in healthy male subjects and smokers. Safety, tolerability and PK data were …
[HTML][HTML] Effects of vercirnon on the activity of CYP3A4, CYP2C19 and CYP2C8 enzymes and BCRP and OATP1B1 transporters using probe substrates
LJ Haberer, I McSherry, A Cargill… - European journal of clinical …, 2014 - Springer
Purpose Vercirnon is a CCR9 chemokine receptor antagonist being developed for the
treatment of Crohn’s disease. As a variety of concomitant medications are often required for the …
treatment of Crohn’s disease. As a variety of concomitant medications are often required for the …
Single‐Dose Pharmacokinetics of the CCR9 Receptor Antagonist Vercirnon in Healthy US and Japanese Subjects
…, T Sakamoto, N Kanemoto, I McSherry… - Clinical …, 2013 - Wiley Online Library
Two randomized, single‐dose, crossover studies were carried out to assess different formulations
and doses of the CCR9 receptor antagonist vercirnon in healthy subjects. US study (n …
and doses of the CCR9 receptor antagonist vercirnon in healthy subjects. US study (n …
The effect of a novel phosphoinositide 3-kinase δ inhibitor (PI3Kδ), GSK2269557, on potential biomarkers measured from the lungs of healthy male smokers
S Worsley, A Amour, A Deans, I McSherry, M Lennon… - 2013 - Eur Respiratory Soc
Phosphatidylinositol (4,5)-bisphosphate (PIP2) is converted by PI3Kδ into Phosphatidylinositol
(3,4,5)-trisphosphate (PIP3). This activates cellular functions including proliferation and …
(3,4,5)-trisphosphate (PIP3). This activates cellular functions including proliferation and …
[BOOK][B] Endothelial Cell Modulation of Smooth Muscle Contraction
IN McSherry - 2005 - search.proquest.com
Arterial diameter is regulated by the cells of the artery wall; the endothelial and smooth muscle
cells. Experiments were designed to investigate the nature of endothelial cell activation …
cells. Experiments were designed to investigate the nature of endothelial cell activation …
[PDF][PDF] ImmunoPET imaging to assess target engagement: Experience from 89Zr‐anti‐HER3 mAb (GSK2849330) in patients with solid tumors
I McSherry, DA Smith, M Cleveland, W Al‐Azzam… - scholar.archive.org
Aim: Positron‐emission tomography (PET) imaging with radiolabeled drug provides
information on tumor uptake and dose‐dependent target interaction to support selection of an …
information on tumor uptake and dose‐dependent target interaction to support selection of an …