Background Leukotrienes are inflammatory mediators generated from arachidonic acid (polyunsaturated
n–6 fatty acid) by the enzyme 5-lipoxygenase. Since atherosclerosis involves …

Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor prognosis and limited
treatment options. Here we provide a comprehensive census of the bone marrow immune …

Polo-like kinase 3 (Plk3, previously termed Prk) contributes to regulation of M phase of the
cell cycle (Ouyang, B., Pan, H., Lu, L., Li, J., Stambrook, P., Li, B., and Dai, W. (1997)J. Biol. …

We show that homotypic and heterotypic mechanisms of LLPS control NUP98–HOXA9
puncta formation, modulating transcriptional activity and transforming hematopoietic cells. …

Background Several epidemiologic studies found weak protective relations between dietary
fiber intake and the risk of cardiovascular disease events. However, few of the studies …

Viruses are linked to a multitude of human illnesses and can disseminate widely in
urbanized environments causing global adverse impacts on communities and healthcare …

We report that interleukin (IL)-17 significantly increases the secretion of CXC chemokine
ligand 1 and 5 (CXCL1/5) from mammary carcinoma cells, and that stimulated secretion of …

The authors evaluated alcohol drinking and cigarette smoking in relation to risk of colorectal
polyps in a Nashville, Tennessee, colonoscopy-based case-control study. In 2003–2005, …

Upon exposure of cells to hydrogen peroxide (H 2 O 2 ) phosphorylation of p53 was rapidly
induced in human fibroblast GM00637, and this phosphorylation occurred on serine 9, …

We defined the spectrum of mutations in relapsed pediatric AML and identified UBTF -TDs
as a new recurrent genetic alteration. These duplications are more common in children and …