NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

The transcriptional regulator STAT3 has key roles in vertebrate development and mature
tissue function including control of inflammation and immunity. Mutations in human STAT3 …

Reversing the dysfunctional T cell state that arises in cancer and chronic viral infections is
the focus of therapeutic interventions; however, current therapies are effective in only some …

The expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a
key mechanism for ensuring immune homeostasis. Dysregulated expression of co-inhibitory …

Emergency supplies supplier selection can be regarded as a classic multiple attribute group
decision making (MAGDM) problem. MAGDM is an interesting everyday problem full of …

Zeolitic imidazolate framework‐8 (ZIF‐8) is an attractive metal organic framework (MOF) in
drug delivery. Strong interaction between drugs and ZIF‐8 is essential for high drug loadings …

Granulocyte colony-stimulating factor (G-CSF) mediates “emergency” granulopoiesis during
infection, a process that is mimicked by clinical G-CSF use, yet we understand little about …

While many drugs are effective at reducing the relapse frequency of multiple sclerosis (MS),
there is an unmet need for treatments that slow neurodegeneration resulting from secondary …

Activating mutations of K-ras are the most common oncogenic alterations found in lung
cancer. Unfortunately, attempts to target K-ras–mutant lung tumors have thus far failed, clearly …