Introduction Synaptic loss is a robust and consistent pathology in Alzheimer's disease (AD)
and the major structural correlate of cognitive impairment. Positron emission tomography (…

Introduction For 30 years synapse loss has been referred to as the major pathological correlate
of cognitive impairment in Alzheimer's disease (AD). However, this statement is based on …

Background Attempts to associate amyloid-β (Aβ) pathogenesis with synaptic loss in
Alzheimer’s disease (AD) have thus far been limited to small numbers of postmortem studies. Aβ …

Sites of early neuropathologic change provide important clues regarding the initial clinical
features of Alzheimer's disease (AD). We have shown significant reductions in hippocampal …

Background Effective, disease-modifying therapeutics for the treatment of Alzheimer’s disease
(AD) remain a large unmet need. Extensive evidence suggests that amyloid beta (Aβ) is …

Background Memory CD8 + T cells expand with age. We previously demonstrated an age-associated
expansion of effector memory (EM) CD8 + T cells expressing low levels of IL-7 …

Objective To investigate associations between statin use and cognitive change, as well as
diagnostic conversion, in individuals with cognitively normal (CN) status, mild cognitive …

Trephination, the practice of boring a hole in the skull, is one of the oldest surgical procedures
performed by and on humans. Fossil records show evidence of trephined skulls on …

DISCUSSION Emboli of foreign bodies to the heart, although unusual, have been reported
with increasing frequency, and have included a diversity of objects from bone spicules to …

CD45RA+ effector memory (EM) CD8+ T cell expansion was reported in Alzheimer’s disease
(AD). Such cells are IL-7 receptor alpha (IL-7Rα) low EM CD8+ T cells, which expand with …