User profiles for Huanhuan Yan

huanhuan yan

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Verified email at siat.ac.cn
Cited by 666

[HTML][HTML] ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation

…, X Cen, X Xu, M Zhang, T Hou, Z Wang, H Yan… - Nature …, 2021 - nature.com
Cancer expression of PD-L1 suppresses anti-tumor immunity. PD-L1 has emerged as a
remarkable therapeutic target. However, the regulation of PD-L1 degradation is not understood. …

[HTML][HTML] Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses

H Zhu, H Yan, NA Tang, X Li, P Pang, H Li… - Nature …, 2017 - nature.com
Choline acetyltransferase neurons in the vertical diagonal band of Broca (vChATs) degenerate
in the early stage of Alzheimer’s disease (AD). Here, we report that vChATs directly …

Antibacterial and hemostatic bilayered electrospun nanofibrous wound dressings based on quaternized silicone and quaternized chitosan for wound healing

Z Gao, C Su, C Wang, Y Zhang, C Wang, H Yan… - European Polymer …, 2021 - Elsevier
The design of novel wound dressings with favorable mechanical properties, hemostasis,
inherent antibacterial function, and biocompatibility to facilitate skin wound healing and inhibit …

[HTML][HTML] Improved hemostatic effects by Fe3+ modified biomimetic PLLA cotton-like mat via sodium alginate grafted with dopamine

C Lv, L Li, Z Jiao, H Yan, Z Wang, Z Wu, M Guo… - Bioactive materials, 2021 - Elsevier
The development of an excellent, bioabsorbable hemostatic material for deep wound remains
a challenge. In this work, a biodegradable cotton-like biomimetic fibrous mat of poly (l-…

[HTML][HTML] Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3-deficient non-human primate

H Zhao, Z Tu, H Xu, S Yan, H Yan, Y Zheng, W Yang… - Cell research, 2017 - nature.com
Despite substantial progress made toward understanding the molecular changes contributing
to autism spectrum disorders (ASD), the neuropathophysiology underlying ASD remains …

Analysis of bond performance of steel bar in steel-polypropylene hybrid fiber reinforced concrete with partially recycled coarse aggregates

D Gao, H Yan, L Yang, Y Pang, B Sun - Journal of Cleaner Production, 2022 - Elsevier
To promote structural sustainability and resource recycling, the bond performance between
steel bars and steel-polypropylene hybrid fiber reinforced recycled aggregate concrete (…

Optimal selection of scalar and vector-valued intensity measures for improved fragility analysis in cross-fault hydraulic tunnels

…, C Wang, W Cui, Q Li, J Xu, X Zhao, H Yan - … and Underground Space …, 2023 - Elsevier
Seismic intensity measures (IMs) are crucial because they are significantly connected to
earthquake hazards and structural responses. It means that selecting appropriate IMs is …

Metformin restores hippocampal neurogenesis and learning and memory via regulating gut microbiota in the obese mouse model

…, H Li, P Pang, F Xue, L Wan, L Pei, H Yan - Brain, Behavior, and …, 2021 - Elsevier
Numerous studies have shown that over-nutritional obesity may lead to pre-diabetes, type 2
diabetes and cognitive decline. As the degree of metabolic disorders increases, the …

Mussel-inspired conducting copolymer with aniline tetramer as intelligent biological adhesive for bone tissue engineering

H Yan, L Li, Z Wang, Y Wang, M Guo… - ACS Biomaterials …, 2019 - ACS Publications
Electrically conducting polymers have been emerging as intelligent bioactive materials for
regulating cell behaviors and bone tissue regeneration. Additionally, poor adhesion between …

Simultaneous realization of highly efficient electromagnetic interference shielding and human motion detection in carbon fiber felt decorated with silver nanowires and …

Z Guo, P Ren, Z Zhang, Z Dai, K Hui, H Yan… - Journal of Materials …, 2021 - pubs.rsc.org
With the flourishing growth of telecommunication and electronics, exploiting multifunctional
conductive polymer composites (CPCs) is highly desirable for wearable electronic devices …