Quantitative tumor oxymetric images from 4D electron paramagnetic resonance imaging (EPRI): methodology and comparison with blood oxygen level‐dependent …

…, GS Karczmar, ED Barth, HJ Halpern - … in Medicine: An …, 2003 - Wiley Online Library
This work presents a methodology for obtaining quantitative oxygen concentration images
in the tumor‐bearing legs of living C3H mice. The method uses high‐resolution electron …

General synthesis of persistent trityl radicals for EPR imaging of biological systems

TJ Reddy, T Iwama, HJ Halpern… - The Journal of organic …, 2002 - ACS Publications
In this paper we describe the syntheses of the tetraoxygenated triarylmethyl (trityl) radical 14
and the tetrathiatriarylmethyl (trityl) radicals 15 and 16. The syntheses include new and …

Oxymetry deep in tissues with low-frequency electron paramagnetic resonance.

HJ Halpern, C Yu, M Peric, E Barth… - Proceedings of the …, 1994 - National Acad Sciences
We have measured the oxygen concentration in the body water of murine FSa and NFSa
fibrosarcomas using a new method for quantitative oxygen concentration determination deep in …

Baicalein attenuates oxidant stress in cardiomyocytes

…, CQ Li, L Dey, E Barth, H Halpern… - American Journal …, 2002 - journals.physiology.org
Flavonoids within Scutellaria baicalensis may be potent antioxidants on the basis of our
studies of S. baicalensis extract. To further this work, we studied the antioxidative effects of …

Imaging radio frequency electron‐spin‐resonance spectrometer with high resolution and sensitivity for invivo measurements

HJ Halpern, DP Spencer, J van Polen… - Review of Scientific …, 1989 - pubs.aip.org
We report the development of a novel radio frequency electron‐spin‐resonance spectrometer
designed to provide measurements with high molar sensitivity and resolution in vivo. …

Electron paramagnetic resonance oxygen images correlate spatially and quantitatively with Oxylite oxygen measurements

…, ED Barth, D Lee, C Haney, HJ Halpern - Clinical Cancer …, 2006 - AACR
Tumor oxygenation predicts cancer therapy response and malignant phenotype. This has
spawned a number of oxymetries. Comparison of different oxymetries is crucial for the …

Absolute oxygen R1e imaging in vivo with pulse electron paramagnetic resonance

…, MK Bowman, C Mailer, HJ Halpern - Magnetic Resonance in …, 2014 - Wiley Online Library
Purpose Tissue oxygen (O 2 ) levels are among the most important and most quantifiable
stimuli to which cells and tissues respond through inducible signaling pathways. Tumor O 2 …

Oxygen-guided radiation therapy

…, RR Weichselbaum, VM Tormyshev, HJ Halpern - International Journal of …, 2019 - Elsevier
Purpose It has been known for over 100 years that tumor hypoxia, a near-universal characteristic
of solid tumors, decreases the curative effectiveness of radiation therapy. However, to …

Electron spin relaxation of triarylmethyl radicals in fluid solution

…, GR Eaton, C Mailer, E Barth, HJ Halpern - Journal of Magnetic …, 2001 - Elsevier
Electron spin relaxation times of a Nycomed triarylmethyl radical (sym-trityl) in water, 1:1
water:glycerol, and 1:9 water:glycerol were measured at L-band, S-band, and X-band by pulsed …

Electron paramagnetic resonance oxygen image hypoxic fraction plus radiation dose strongly correlates with tumor cure in FSa fibrosarcomas

…, CA Pelizzari, M Kocherginsky, HJ Halpern - International Journal of …, 2008 - Elsevier
PURPOSE: Tumor hypoxia has long been known to produce resistance to radiation. In this
study, electron paramagnetic resonance (EPR) oxygen imaging was investigated for its …